ArticleNeuroprotection (Chichester, England)2024
Intracranial pressure is elevated at 24 h post-stroke in mice.
Article in Neuroprotection (Chichester, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The Cerebral Lymphatic System: Function, Controversies, and Therapeutic Approaches for Central Nervous System Diseases.Cellular and molecular neurobiology · 2025Review
- Intracranial pressure is elevated at 24 h post-stroke in mice.Neuroprotection (Chichester, England) · 2024Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: It has long been assumed that post-stroke intracranial pressure (ICP) elevation occurs because of large infarct and edema volumes. However, we have repeatedly shown ICP elevation at 24 h post-stroke in the presence of little to no edema in rats. Biological processes are often conserved across species and types of injury. Therefore, we aimed to determine if an ICP rise occurs at 24 h post-stroke in the presence of small infarct and edema volumes in mice. Methods: Mice were randomized by random number table to either photothrombotic stroke or sham surgery ( Results: ICP was significantly higher at 24 h compared to baseline in stroke animals ( Conclusion: This study provides evidence of an edema-independent ICP elevation following small ischemic stroke in mice. The occurrence of this rise supports our findings in other species and suggests it is caused by a previously undescribed mechanism.
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