ReviewNeuroprotection (Chichester, England)2024
A novel perspective in stroke neuroprotection: Leveraging hypoxic pocket insights for studying preconditioning and postconditioning.
Review in Neuroprotection (Chichester, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Diabetic cerebral microvascular disorder: from key pathologies to targeted interventions.Annals of medicine · 2026Review
- Article
- Cerebral autoregulation in patients with acute lacunar infarction: a reliable predictor of outcome.Annals of clinical and translational neurology · 2025Article
- Prediction of outcomes following intravenous thrombolysis in patients with acute ischemic stroke using serum UCH-L1, S100β, and NSE: a multicenter prospective cohort study employing machine learning methods.Therapeutic advances in neurological disorders · 2025Article
- A novel perspective in stroke neuroprotection: Leveraging hypoxic pocket insights for studying preconditioning and postconditioning.Neuroprotection (Chichester, England) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This perspective article delineates the significant role of hypoxic pockets-localized, transient reductions in cerebral oxygenation-and their implications for stroke neuroprotection strategies. It posits that preconditioning and postconditioning, through interventions like isoflurane, exercise, remote limb ischemic conditioning, can mitigate these hypoxic pockets, potentially protecting the brain against ischemic events. These strategies exploit the brain's intrinsic adaptive capabilities to resist ischemic damage, underscoring a novel avenue for enhancing recovery and prevention efforts. The study emphasizes the need for further exploration into optimizing these interventions to harness their full potential in combating stroke's debilitating effects, marking a pivotal shift towards targeted neuroprotective measures focused on cerebral microenvironmental optimization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.