SynthesisFrontiers in nutrition2025
The impact of high fructose corn syrup on liver injury and glucose metabolism: a systematic review.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Consumption of Fructose by Cultured Primary Rat Astrocytes.Neurochemical research · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: High fructose corn syrup (HFCS) is a dietary sweetener that is used in a substantial portion of food and beverages. Recent evidence has cited dietary HFCS as a risk factor in the development of obesity, metabolic syndrome, and liver disease. This systematic review provides a new evaluation of the potential hepatic and metabolic risks posed by HFCS to inform both clinical practice and public health policy. Methods: We conducted a systematic review of English-language, human studies of adults (≥18 years) with low to no alcohol intake using Covidence. Only quantitative studies that specified a link supported by direct evidence between HFCS and markers of liver injury or glucose metabolism in the setting of MASLD or NAFLD were included. Results: The literature search yielded 23,006 studies. After removing duplicates, 16,955 studies were screened and 16,930 were excluded after abstract screening. 20 texts were reviewed in full; 19 were excluded. 1 study was included after study selection. Conclusion: This review identifies and critically appraises the methodological strengths and limitations of the sole study meeting eligibility criteria. The 2022 study by Sigala et al. involved a non-randomized, controlled dietary intervention examining the dose-response effects of high-fructose corn syrup (HFCS) on hepatic lipid accumulation and insulin sensitivity in healthy adults. The identification of only a single eligible study emphasizes a stark absence of focused investigations in this area. Given the increasingly widespread consumption of HFCS and its prevalence in the modern food supply, this scarcity of research is concerning. Further research in this area should focus on clinical studies of longer duration, comparative studies of HFCS and other sugars, and incorporate greater demographic and geographic diversity.
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Registered trials
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