SynthesisFrontiers in neurology2025
Efficacy and safety of flow diverters in small intracranial aneurysms: a systematic review and single-arm meta-analysis.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Twelve-Month Outcomes of the J-Tube Flow-Diverting Stent for Unruptured Intracranial Aneurysms: a Prospective Multicenter Study.Clinical neuroradiology · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to evaluate the efficacy and safety of flow diverters (FDs) in the treatment of small intracranial aneurysms (≤10 mm). Methods: PubMed, Embase, Web of Science, and Cochrane Library were comprehensively searched up to July 2025. Eligible studies included retrospective cohort studies reporting angiographic and clinical outcomes of FD treatment in small intracranial aneurysms. Data analysis was conducted using STATA 15.0. Pooled proportions and 95% confidence intervals (CIs) were calculated using Freeman-Tukey double arcsine transformation. Publication bias was evaluated using funnel plots and Egger's test. Results: Ten retrospective studies comprising 2,275 patients with 1,938 aneurysms were included. The pooled complete or near-complete occlusion rate was 86% (95% CI: 80-92%). The treatment-related mortality rate was 1% (95% CI: 0-2%), and the hemorrhagic event rate was 1% (95% CI: 1-2%). The ischemic event rate was 2% (95% CI: 1-3%), and the stroke rate was 3% (95% CI: 1-5%). The overall complication rate was 9% (95% CI: 5-12%), while 98% (95% CI: 94-100%) of patients achieved favorable functional outcomes. Egger's test showed no significant publication bias ( Conclusion: FDs appear to be both effective and safe for the treatment of small intracranial aneurysms, achieving high occlusion rates and favorable functional outcomes with low rates of mortality and complications. However, given the high heterogeneity and retrospective nature of the included studies, further large-scale prospective studies are warranted to confirm these findings and refine treatment strategies.
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