Videonystagmography features and clinical symptoms correlate with Parkinson's clinical subtypes.

Objective: Analyzing the differences in video-nystagmography (VNG) parameters among Parkinson's disease (PD) patients with distinct motor subtypes and evaluate the correlation between VNG parameters and the severity of non-motor symptoms (NMS) in Tremer Dominant (TD)/Postural Instability/Gait Difficulty (PIGD) subtypes provides a theoretical basis for advancing the understanding of PD heterogeneity. Methods: Sixty-nine patients with PD diagnosed in the Department of Neurology of the First Affiliated Hospital of Hainan Medical College from December 2022 to January 2024 were collected. Among them, 35 were in the Tremer Dominant (TD) group, 34 were in the Postural Instability/Gait Difficulty (PIGD) group, and 38 patients with physical examination admitted in the same period were collected as the healthy control (HC) group. The subjects were assessed for motor and non-motor symptoms, and the VNG was refined to record the assessment of eye movement abnormalities in the patients. The general clinical data and VNG parameters of the subjects in the three groups were analyzed and correlation analyses were performed for clinical features and nystagmus views with intergroup differences in the PIGD and TD groups. Results: There were significant differences in VNG parameters among the three groups of subjects, mainly in vertical sweep latency and solid-phase microextraction (SPEM) vertical gain ( Conclusion: VNG shows significant differences among Parkinson's disease patients with different motor subtypes, and VNG features are correlated with non-motor symptoms.