ArticleClinical transplantation2025
Outcomes of Persistent Microvascular Inflammation in Repeated Kidney Allograft Biopsies.
Article in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Outcomes of Persistent Microvascular Inflammation in Repeated Kidney Allograft Biopsies.Clinical transplantation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundMicrovascular inflammation (MVI) with sum glomerulitis and peritubular capillaritis (g+ptc) ≥ 2 is an integral component of kidney allograft antibody-mediated rejection (AMR). It is unclear what the outcomes are among those with persistent MVI, despite treatment.
methodsWe included all kidney transplant recipients (KTRs) with persistent MVI ≥ 2 on first and second allograft biopsies who had third biopsies within 2 years of the first biopsy. KTRs were categorized into two groups, MVI (+) and MVI (-) on third biopsy. Risk factors for persistent MVI ≥ 2 on third biopsy, and graft survival based on MVI (+) and MVI (-) at last follow-up were outcomes of interest.
resultsA total of 108 KTRs transplanted between 2013 and 2022 fulfilled our selection criteria, 75 (69%) were MVI (+) and 33 (31%) MVI (-). Most baseline characteristics were similar between the groups. In Cox regression analysis, none of the commonly assessed baseline characteristics, Banff scores, or DSA status at first or second biopsy were associated with persistent MVI on the third biopsy. Also, in Cox regression analysis, after adjusting for various characteristics, persistent MVI on third biopsy was not associated with increased or decreased risk for uncensored graft failure (aHR: 0.55, 95% CI: 0.23-1.29; p = 0.17).
conclusionThe lack of difference in graft outcomes between the AMR patients who were MVI (+) versus MVI (-) on the third biopsy suggests that subsequent response to AMR treatment is less important for prognosis than the initial development of AMR. This reinforces the importance of the prevention of rejection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.