Evidence map›Paper›PMID 41382993›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025

[Effects of lunar soil simulant and Earth soil on lung injury in mice].

Xiaoxiao Gong, Shiyue He, Yixiao Chen, Yiwei Liu, Qiyun Cheng, Ya Chen, Xinyue Hu, Zhenxing Wang, Hui Xie

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xiaoxiao GongDepartment of Respiratory and Critical Care Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha 410008. 248102083@csu.edu.cn.
Shiyue HeDepartment of Respiratory and Critical Care Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha 410008. heshiyue1999@qq.com.
Yixiao ChenDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008.
Yiwei LiuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008.
Qiyun ChengDepartment of Pathology, Xiangya School of Basic Medical Sciences, Central South University, Changsha 410078.
Ya ChenDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008.
Xinyue HuDepartment of Respiratory and Critical Care Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha 410008.
Zhenxing WangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008. wangzx@csu.edu.cn.
Hui XieDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008. huixie@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDue to prolonged exposure to cosmic radiation and meteorite impacts, lunar surface dust forms nanoscale angular particles with strong electrostatic adsorption properties. These dust particles pose potential inhalation risks, yet their pulmonary toxicological mechanisms remain unclear. Given the need for dust exposure protection in future lunar base construction and resource development, this study established an acute exposure model using lunar soil simulant (LSS) and used Earth soil (ES; Loess from Shaanxi, China) as a comparison to investigate lung injury mechanisms.

methodsC57BL/6 mice were randomly assigned to 3 groups: Phosphate buffered saline (PBS), LSS, and ES, with 5 to 7 mice per group. Mice in the LSS and ES groups received a single intratracheal instillation to induce acute inhalation exposure. Body weight was monitored for 28 days. Mice were euthanized at days 3, 7, 14, and 28 post-exposure, and peripheral blood, bronchoalveolar lavage fluid (BALF), and lung tissues were collected. Immune cell subsets in BALF were analyzed using flow cytometry. Hematoxylin-eosin (HE) staining assessed lung structure and inflammation; periodic acid-Schiff (PAS) staining evaluated airway mucus secretion; Masson staining examined collagen deposition. Real-time reverse transcription PCR (real-time RT-PCR) was used to measure the mRNA expression of inflammatory cytokines (

resultsBody weight in the ES group progressively declined after day 18 (all

conclusionsBoth LSS and ES can induce sustained lung injury and neutrophil infiltration in mice, though the underlying molecular mechanisms differ. Compared with ES, exposure to LSS additionally triggers a transient eosinophilic response, suggesting that lunar dust particles possess stronger immunostimulatory potential and higher biological toxicity.

Indexed as

DustLung InjuryMoonSoilAnimalsBronchoalveolar Lavage FluidInhalation ExposureLungMaleMiceMice, Inbred C57BLDustSoilchemokinesdust exposureEarth soillunar soil simulantlung injury

Identifiers

PMID41382993
PMCPMC12723257

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.