Evidence map›Paper›PMID 41382992›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025

[Toxicity of lunar dust simulant exposure via the digestive system: Microbiota dysbiosis and multi-organ injury].

Yixiao Chen, Yiwei Liu, Shiyue He, Xiaoxiao Gong, Qiyun Cheng, Ya Chen, Xinyue Hu, Zhenxing Wang, Hui Xie

Abstract readEnglish Abstract
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Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yixiao ChenDepartment of Orthopaedic Surgery, Xiangya Hospital, Central South University, Changsha 410008. 238111114@csu.edu.cn.
Yiwei LiuDepartment of Orthopaedic Surgery, Xiangya Hospital, Central South University, Changsha 410008. liuywxy@csu.edu.cn.
Shiyue HeDepartment of Respiratory and Critical Care Medicine, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha 410008.
Xiaoxiao GongDepartment of Respiratory and Critical Care Medicine, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha 410008.
Qiyun ChengDepartment of Pathology, Xiangya School of Basic Medical Sciences, Central South University, Changsha 410078.
Ya ChenDepartment of Orthopaedic Surgery, Xiangya Hospital, Central South University, Changsha 410008.
Xinyue HuDepartment of Respiratory and Critical Care Medicine, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha 410008.
Zhenxing WangDepartment of Orthopaedic Surgery, Xiangya Hospital, Central South University, Changsha 410008. wangzx@csu.edu.cn.
Hui XieDepartment of Orthopaedic Surgery, Xiangya Hospital, Central South University, Changsha 410008. huixie@csu.edu.cn.

Funding

the Fundamental Research Funds for the Central Universities of Central South University 2024ZZTS0887
6 · The paper itself

Abstract

objectivesAs early as the Apollo 11 mission, astronauts experienced ocular, skin, and upper airway irritation after lunar dust (LD) was brought into the return cabin, drawing attention to its potential biological toxicity. However, the biological effects of LD exposure through the digestive system remain poorly understood. This study aimed to evaluate the impact of digestive exposure to lunar dust simulant (LDS) on gut microbiota and on the intestine, liver, kidney, lung, and bone in mice.

methodsEight-week-old female C57BL/6J mice were used. LDS was used as a substitute for lunar dust, and Shaanxi loess was used as Earth dust (ED). Mice were randomly divided into a phosphate buffered saline (PBS) group, an ED group (500 mg/kg), and a LDS group (500 mg/kg), with assessments at days 7, 14, and 28. Mice were gavaged once every 3 days, with body weight recorded before each gavage. At sacrifice, fecal samples were analyzed by 16S ribosomal RNA (rRNA) sequencing; inflammatory cytokine expression [interleukin (

resultsAt day 10, weight gain was slowed in ED and LDS groups. At days 22 and 28, body weight in both ED and LDS groups was significantly lower than controls (both

conclusionsLDS exposure via the digestive route induces gut dysbiosis, intestinal barrier disruption, pulmonary inflammation, bone loss, and bone marrow immune imbalance. These findings indicate that LD exposure poses potential health risks during future lunar missions. Targeted restoration of beneficial gut microbiota may represent a promising strategy to mitigate LD-related health hazards.

Indexed as

Digestive SystemDustDysbiosisGastrointestinal MicrobiomeMoonAnimalsFemaleKidneyLiverLungMiceMice, Inbred C57BLDustgut microbiotaintestinal barrierlunar dust simulantlunar explorationosteoporosispneumonia

Identifiers

PMID41382992
PMCPMC12723248

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.