ArticleRomanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
The influence of diabetes mellitus on blood vessels' amounts and immune status in case of breast cancer.
Article in Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The influence of diabetes mellitus on blood vessels' amounts and immune status in case of breast cancer.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast cancer (BC) remains one of the most prevalent malignancies worldwide, and its progression can be influenced by systemic conditions such as type 2 diabetes mellitus (T2DM). Both diseases share common mechanisms of metabolic dysregulation, chronic inflammation, and vascular dysfunction that may reshape the tumor microenvironment (TME).
aimTo conduct a comparative evaluation of the vascular and immune components of the BC microenvironment in patients with and without T2DM, as well as in normal mammary tissue, with particular emphasis on cluster of differentiation (CD)34+ microvessel density (MVD), T-cell subsets (CD3+, CD4+, CD8+), and their association with hormonal receptor status and proliferative index (Ki67). MATERIALS AND
methodsImmunohistochemical analysis was performed on 58 invasive ductal carcinomas (29 T2DM-associated, 29 non-diabetic) and 10 normal breast samples. Quantification of immune and vascular markers was correlated with clinical and morphological parameters using Spearman's test and Welch statistics (p≤0.05).
resultsT2DM-associated BCs demonstrated significantly increased intratumoral MVD (p=0.03) and decreased intratumoral CD3+, CD4+, and CD8+ lymphocytes compared with non-diabetic tumors, indicating an immune-excluded phenotype. Blood glucose correlated positively with CD34+ vessel content and inversely with Ki67 expression (rs=-0.29, p=0.05). Peritumoral CD8+ cells were positively associated with estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) status, suggesting hormonal modulation of immune infiltration.
conclusionsT2DM promotes vascular proliferation and suppresses intratumoral immune activity in BC, creating an angiogenic yet immunosuppressed microenvironment. These findings highlight the impact of metabolic imbalance on tumor biology and underscore the need for integrating metabolic control and immunomodulatory strategies in the management of diabetic BC patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.