ArticleBMC ophthalmology2025
Assessment of macular vessel density by optical coherence tomography angiography after sub-scleral trabeculectomy in patients with primary open angle glaucoma.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Evaluation of Posterior Segment Structural and Vascular Changes After Gonioscopy-Assisted Transluminal Trabeculotomy.Diagnostics (Basel, Switzerland) · 2026Article
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3 authors.
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Abstract
objectivesTo evaluate the changes in macular vascular density (VD), ganglion cell complex GCC thickness, and Fovea Avascular Zone (FAZ) Area at one and six months after Sub-Scleral Trabeculectomy SST with mitomycin C (MMC) in patients with Primary Open Angle Glaucoma POAG and correlate those changes with reduction of IOP using optical coherence tomography angiography (OCTA).
methodsThirty eyes of 30 patients with POAG who underwent SST with MMC were prospectively evaluated. OCTA (AngioVue, Optovue) was used before surgery and at one and six months after surgery to quantify the vascular density of superficial capillary plexus (SCP-VD), deep capillary plexus (DCP-VD), whole image (WI-VD), fovea (F-VD), Parafovea (PAF-VD), Perifovea (PER-VD), in addition to the GCC thickness, FAZ area (FAZ-A), FAZ perimeter (FAZ-P), and foveal density (FD).
resultsAll patients showed a significant reduction in mean IOP at each follow-up from (31.31 ± 4.52) preoperatively to 14.19 ± 2.10 and 13.75 ± 1.27 mmHg at one month and six months postoperative, respectively (p < 0.001). There was a significant improvement in macular deep capillary plexus DCP-VD in all parameter's values (p < 0.001). The mean whole-image DCP-VD increased from 48.19 ± 2.20% preoperatively to 49.50 ± 2.30% at one month and 53.38 ± 1.78% at six months postoperatively. Similar significant increases were observed in the foveal, parafoveal and perifoveal regions. The FAZ area decreased significantly from 0.398 ± 0.062 mm² preoperatively to 0.357 ± 0.060 mm² at one month and 0.372 ± 0.058 mm² at six months (p = 0.010). The FAZ perimeter also showed a significant reduction from 2.238 ± 0.385 mm preoperatively to 1.889 ± 0.350 mm at one month and 2.075 ± 0.293 mm at six months (p = 0.001). Foveal density increased significantly from 46.88 ± 1.81% preoperatively to 48.52 ± 2.00% at one month and 49.71 ± 2.56% at six months (p < 0.001). Postoperative increases in macular SCP-VD and GCC thickness were minimal and not statistically significant (p > 0.05). A significant negative correlation was found between IOP reduction and DCP-VD at six months (p < 0.05), whereas IOP reduction correlated positively with decreases in FAZ area and perimeter at one month (p = 0.011, p = 0.027) and six months (p = 0.010, p = 0.029).
conclusionOCTA revealed significant postoperative improvement in deep macular vessel density and FAZ metrics following SST with MMC. These findings highlight the vascular benefits of surgical IOP reduction in restoring macular microcirculation among patients with POAG.
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