Evidence map›Paper›PMID 41382294›Full record

ArticleBiology of sex differences2025

Sex-related upregulation of bone morphogenetic protein signaling inhibits adult neurogenesis in APP

Xingyu Su, Rina Takayanagi, Hiroki Maeda, Takaomi C Saido, Toshio Ohshima

Abstract read
In one paragraph

Article in Biology of sex differences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xingyu SuDepartment of Life Science and Medical Bioscience, Waseda University, Shinjuku- ku, Tokyo, 162-8480, Japan.
Rina TakayanagiDepartment of Life Science and Medical Bioscience, Waseda University, Shinjuku- ku, Tokyo, 162-8480, Japan.
Hiroki MaedaDepartment of Life Science and Medical Bioscience, Waseda University, Shinjuku- ku, Tokyo, 162-8480, Japan.
Takaomi C SaidoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-shi Saitama, 351-0198, Japan.
Toshio OhshimaDepartment of Life Science and Medical Bioscience, Waseda University, Shinjuku- ku, Tokyo, 162-8480, Japan. ohshima@waseda.jp.

Funding

Japan Society for the Promotion of Science JP22K06464
6 · The paper itself

Abstract

backgroundBone morphogenetic proteins (BMPs) have been reported in many studies to be related to adult neurogenesis. Neurogenic impairment is a hallmark of Alzheimer's disease (AD), while the involvement of BMPs remains unclear.

methodsAD models were established using APP

resultsOur study revealed that APP

conclusionsOur findings reveal a sex-dependent impairment of neurogenesis in APP

Indexed as

Alzheimer DiseaseBone Morphogenetic ProteinsNeurogenesisSex CharacteristicsAnimalsDisease Models, AnimalEstrogensFemaleHippocampusMaleMiceMice, Inbred C57BLMice, TransgenicNeural Stem CellsSignal TransductionUp-RegulationBone Morphogenetic ProteinsEstrogens

Identifiers

PMID41382294
PMCPMC12699841

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.