Evidence map›Paper›PMID 41382243›Full record

ArticleActa neuropathologica communications2025

Prognostic relevance of MIB-1 labeling index in VHL-associated and sporadic spinal hemangioblastomas: a subgroup analysis from a multicentric study.

Johannes Wach, Alim Emre Basaran, Obada T Alhalabi, Jürgen Beck, Vicki M Butenschoen, Steven D Chang, Marcus Czabanka, Tomasz Czernicki, Philipp Dammann, Roberto Doria-Medina and 30 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Johannes Wach *Department of Neurosurgery, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany. johannes.wach@medizin.uni-leipzig.de.
Alim Emre Basaran *Department of Neurosurgery, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Obada T AlhalabiDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Jürgen BeckDepartment of Neurosurgery, Medical Center-University of Freiburg, Freiburg im Breisgau, Germany.
Vicki M ButenschoenDepartment of Neurosurgery, School of Medicine, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.
Steven D ChangDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Marcus CzabankaDepartment of Neurosurgery, University Hospital Frankfurt, Frankfurt am Main, Germany.
Tomasz CzernickiDepartment of Neurosurgery, Medical University of Warsaw, Warsaw, Poland.
Philipp DammannDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany.
Roberto Doria-MedinaDepartment of Neurosurgery, Medical Center-University of Freiburg, Freiburg im Breisgau, Germany.
Sven Oliver EickerDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Alonso Barrantes-FreerPaul-Flechsig-Instiute of Neuropathology, University of Leipzig Medical Center, 04103, Leipzig, Germany.
Christine GizawDepartment of Neurosurgery, Medical Center-University of Freiburg, Freiburg im Breisgau, Germany.
Erdem GüresirDepartment of Neurosurgery, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Marc HohenhausDepartment of Neurosurgery, Medical Center-University of Freiburg, Freiburg im Breisgau, Germany.
Romina HohenhausDepartment of Neurosurgery, Medical Center-University of Freiburg, Freiburg im Breisgau, Germany.
Ahed H KattaaDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Fatma KilincDepartment of Neurosurgery, University Hospital Frankfurt, Frankfurt am Main, Germany.
Lukas KleinDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Nikolaus KöglDepartment of Neurosurgery, Medical University Innsbruck, Innsbruck, Austria.
Sandro KriegDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Przemyslaw KunertDepartment of Neurosurgery, Medical University of Warsaw, Warsaw, Poland.
Maximilian MiddelkampDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Bernhard MeyerDepartment of Neurosurgery, School of Medicine, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.
Nicolas NeidertDepartment of Neurosurgery, Medical Center-University of Freiburg, Freiburg im Breisgau, Germany.
Julia OnkenDepartment of Neurosurgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Tobias PantelDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
David J ParkDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Laurèl RauschenbachDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany.
Roman SankowskiInstitute of Neuropathology, Faculty of Medicine, Medical Center-University of Freiburg, 79106, Freiburg, Germany.
Alejandro N SantosDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany.
Nils Ole SchmidtDepartment of Neurosurgery, University Hospital, University of Regensburg, Regensburg, Germany.
Sebastian SillerDepartment of Neurosurgery, University Hospital, University of Regensburg, Regensburg, Germany.
Ulrich SureDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany.
Claudius ThoméDepartment of Neurosurgery, Medical University Innsbruck, Innsbruck, Austria.
Tarik TihanDivision of Neuropathology, UCSF School of Medicine, San Francisco, CA, USA.
Martin VychopenDepartment of Neurosurgery, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Peter VajkoczyDepartment of Neurosurgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Maria WostrackDepartment of Neurosurgery, School of Medicine, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.
Jan-Helge KlinglerDepartment of Neurosurgery, Medical Center-University of Freiburg, Freiburg im Breisgau, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal hemangioblastomas (sHB) are rare vascular tumors, with distinct clinical courses between von Hippel-Lindau (VHL)-associated and sporadic cases. The MIB-1 labeling index has been proposed as a surrogate marker for tumor proliferation, but its prognostic value remains unclear in this context. In this subgroup analysis from a multicenter retrospective study, we analyzed 116 primary sHB patients with available MIB-1 indices. Patients were stratified by VHL status. Statistical comparisons included ROC analyses for local progression-free survival (PFS) prediction and Kaplan-Meier survival curves for local PFS, stratified by a MIB-1 index cut-off derived from Youden's index. The MIB-1 index was significantly lower in VHL-associated tumors compared to sporadic ones (mean 2.17% vs. 3.02%, p = 0.008). In VHL-associated sHB, a higher MIB-1 index (≥ 2%) correlated with an increased risk of local tumor progression (AUC 0.74, 95% CI 0.49-0.98), whereas this was not observed in sporadic cases (AUC 0.56, 95% CI 0.23-0.88). Kaplan-Meier analysis showed that VHL patients with MIB-1 ≥ 2% had significantly shorter PFS (p = 0.05), while no significant association was found in sporadic tumors (p = 0.87). Our findings suggest that while VHL-associated sHB exhibit lower proliferative indices overall, elevated MIB-1 labeling indices might serve as a prognostic marker of shorter local PFS in this subgroup. In contrast, MIB-1 index appears to have limited prognostic relevance in sporadic sHB. These results highlight the importance of further molecular stratification and proliferation assessment in sHB to better inform clinical decision-making.

Indexed as

HemangioblastomaKi-67 AntigenSpinal Cord Neoplasmsvon Hippel-Lindau DiseaseAdolescentAdultAgedBiomarkers, TumorFemaleHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisProgression-Free SurvivalRetrospective StudiesBiomarkers, TumorKi-67 AntigenVon Hippel-Lindau Tumor Suppressor ProteinLocal tumor progressionMIB-1 indexProgression-free survivalSpinal hemangioblastomaVon Hippel-Lindau disease

Identifiers

PMID41382243
PMCPMC12801762

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