Evidence map›Paper›PMID 41382228›Full record

ArticleEuropean journal of medical research2025

Risk factors associated with bone cement leakage following percutaneous kyphoplasty: a retrospective analysis.

Weibin Mao, Liping Fan, Aiqi Zhang, Jiahui Tong, Xiaodi Zou, Jiamin Qian, Jiahao Chen, Zhe Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Weibin MaoThe Second Clinical Medical College of Zhejiang, Chinese Medical University, Hangzhou, Zhejiang, China.
Liping FanDepartment of Orthopedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Aiqi ZhangThe Second Clinical Medical College of Zhejiang, Chinese Medical University, Hangzhou, Zhejiang, China.
Jiahui TongDepartment of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
Xiaodi ZouThe Second Clinical Medical College of Zhejiang, Chinese Medical University, Hangzhou, Zhejiang, China.
Jiamin QianThe Second Clinical Medical College of Zhejiang, Chinese Medical University, Hangzhou, Zhejiang, China.
Jiahao ChenThe Second Clinical Medical College of Zhejiang, Chinese Medical University, Hangzhou, Zhejiang, China.
Zhe ChenDepartment of Orthopedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. zhechen@zcmu.edu.cn.

Funding

National Nature and Science Foundation of China 81873128the National Natural Science Foundation of China 81873128the Zhejiang Province Traditional Chinese Medicine Science and Technology Project No.2023ZL461
6 · The paper itself

Abstract

backgroundPercutaneous kyphoplasty (PKP) is a minimally invasive procedure in which bone cement is injected into a damaged vertebral body to rapidly alleviate pain and stabilize the spine. The most common complication associated with this procedure is bone cement leakage. Following leakage, compression can occur, potentially leading to severe clinical consequences such as paraplegia, spinal cord compression, cement pulmonary embolism, and even death. This study aims to analyze the risk factors for bone cement leakage in patients with osteoporotic vertebral compression fractures (OVCF) following PKP, and to develop a nomogram to predict the risk of recurrent fractures.

methodsThis retrospective cohort study included 308 patients with osteoporotic vertebral compression fractures (OVCF) who underwent percutaneous kyphoplasty (PKP) treatment between January 2021 and December 2024 involving 349 vertebral bodies. The patients were divided into two groups based on the presence or absence of bone cement leakage: the control group (n = 280) and the cement leakage group (n = 69). Clinical, imaging, and surgical data were analyzed, and the following potential risk factors were identified: age, gender, height, weight, BMI, hypertension, diabetes, disease duration, trauma, fracture site, volume of bone cement, NRS (Numerical Rating Scale), bone mineral density (BMD), preoperative vertebral height, postoperative vertebral height, type of vertebral fracture, cortical continuity status of the vertebral body, integrity of the posterior wall, intervertebral vacuum cleft (IVC), and Cobb angle. Based on these factors, we established a Lasso-logistic regression model and evaluated its predictive performance using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA). Finally, the model was visualized, and a nomogram was generated. This study followed the STROBE reporting guidelines.

resultsBinary logistic regression revealed that hypertension, the degree of vertebral collapse, cortical continuity status of the vertebral body, intact posterior wall, segments (T6, T8), and the volume of bone cement are independent risk factors for bone cement leakage.

Indexed as

Bone CementsFractures, CompressionKyphoplastyOsteoporotic FracturesPostoperative ComplicationsSpinal FracturesAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsBone CementsCement leakageNomogramOsteoporotic vertebral compression fracturesPercutaneous kyphoplasty

Identifiers

PMID41382228
PMCPMC12801660

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.