Evidence map›Paper›PMID 41382148›Full record

ArticleBMC endocrine disorders2025

Comparison of logistic regression and artificial neural network models for predicting hypoglycemia in non-ICU inpatients with diabetes.

Fei Shao, Guifang Lin, Feihui Zeng, Libin Liu, Jie You, Bangwei Zeng

Abstract readComparative Study
In one paragraph

Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Fei Shao *Department of Endocrinology and Metabolism Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, 350001, China.
Guifang Lin *Department of Endocrinology and Metabolism Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, 350001, China.
Feihui ZengDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, 350001, China.
Libin LiuDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, 350001, China.
Jie YouDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, 350001, China. youjie@fjmu.edu.cn.
Bangwei ZengAdministration Department of Nosocomial Infection, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, 350001, China. fallwin@fjmu.edu.cn.

Funding

Libin Liu Joint Funds for the innovation of Science and Technology
6 · The paper itself

Abstract

aimTo analyze data from non-intensive care unit (non-ICU) inpatients with diabetes to predict the risk of hypoglycemia using electronic health records (EHRs) and point-of-care (POC) blood glucose values.

methodsPatient demographics, laboratory results, POC blood glucose, and procedures were performed during the hospital stays on Days 0-2 to predict hypoglycemic episodes (blood glucose ≤ 3.9 mmol/L) on Days 3-6. The dataset was randomly split into a training set and an independent verification set at a 7:3 ratio. Logistic Regression (LR) and Artificial Neural Network (ANN) were compared using the area under the curve (AUC). A nomogram plot was also constructed to display the predicted hypoglycemia probabilities.

resultsData from 16,593 diabetic patients (January 2017 to June 2022) were analyzed. Predictive factors from the LR model included the use of insulin; previous hypoglycemia in Days 0-2; respiratory rate; blood urea nitrogen; potassium; D-dimer levels; coefficient variation of blood glucose (BG CV) > 31%; and blood glucose gap (BG gap, maximum of blood glucose - minimum of blood glucose) > 10 mmol/L. In the verification set, the AUC of ANN was 0.762 and the AUC of LR was 0.763. There was no significant difference in the effects of the models built by the two methods. The results showed that the probability predicted by the nomogram using LR is similar to the clinical results. Decision curve analysis (DCA) indicated potential clinical application for the LR model.

conclusionsThe LR model demonstrated considerable value in predicting hypoglycemia risk, comparable to ANN. Trials of such models should be conducted to evaluate their utility in reducing inpatient hypoglycemia. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Diabetes MellitusHypoglycemiaNeural Networks, ComputerAdultAgedBlood GlucoseElectronic Health RecordsFemaleFollow-Up StudiesHumansInpatientsLogistic ModelsMaleMiddle AgedPrognosisRetrospective StudiesBlood GlucoseArtificial neural networkGlycemic variabilityHypoglycemiaInpatient diabetesPrediction

Identifiers

PMID41382148
PMCPMC12802217

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.