ReviewStem cell reviews and reports2026
Hypothesis: Stem Cells Improve Skin Rejuvenation Through Multiple Signaling Pathways.
Review in Stem cell reviews and reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The skin is the body's most fundamental protective barrier but also a prominent indicator of aging. Skin aging is a complex process influenced by both intrinsic and extrinsic factors. In recent years, stem cell therapy has emerged as a novel approach widely applied in the field of skin rejuvenation. However, how Mesenchymal Stem Cells (MSCs) coordinately and dynamically regulate this network of pathways remains largely unknown. We propose an integrative hypothesis: MSCs improve skin rejuvenation through a dynamic, interactive multi-pathway network, exhibiting temporal and spatial specificity. We hypothesize that MSCs can dynamically regulate multiple signaling pathways at different levels, including MAPK, TGF-β/Smad, PI3K/Akt, Wnt/β-catenin, Notch, NF-κB, and Nrf2, to exert their therapeutic effects. By modulating the interactions between these pathways, including synergistic or antagonistic effects, and regulating various cellular responses such as anti-oxidation, anti-apoptosis, anti-inflammation, and promotion of dermal fibroblast proliferation, MSCs achieve skin rejuvenation. This knowledge may contribute to the future development of more precise targeted therapies and help in formulating tailored treatment strategies, potentially optimizing efficacy and mitigating the risk of subsequent complications.
Indexed as
Identifiers
41381980What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.