Evidence map›Paper›PMID 41381906›Full record

ArticleNature cardiovascular research2025

Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia.

Abigail V Giles, Raul Covian, Hiran A Prag, Nils Burger, Bertrand Lucotte, Chak Shun Yu, Junhui Sun, Elizabeth Murphy, Thomas Krieg, Michael P Murphy and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Abigail V GilesNHLBI, National Institutes of Health, Bethesda, MD, USA.
Raul CovianNHLBI, National Institutes of Health, Bethesda, MD, USA.
Hiran A PragDepartment of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-4753-8567
Nils BurgerMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Bertrand LucotteNHLBI, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-1646-1384
Chak Shun YuMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0009-0004-3106-9681
Junhui SunNHLBI, National Institutes of Health, Bethesda, MD, USA.
Elizabeth MurphyNHLBI, National Institutes of Health, Bethesda, MD, USA.
Thomas KriegDepartment of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5192-580X
Michael P MurphyMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. mpm37@cam.ac.uk.ORCID http://orcid.org/0000-0003-1115-9618
Robert S BalabanNHLBI, National Institutes of Health, Bethesda, MD, USA. balabanr@nhlbi.nih.gov.ORCID http://orcid.org/0000-0003-4086-0948

Funding

Control Of Cellular Energy MetabolismZIAHL004601 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BALABAN, ROBERT · 2009 to 2023
$24.4M
Mechanisms of cardiac ischemia-reperfusion injury and cardioprotectionZ01HL002066 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2008 to 2008
$607k
British Heart Foundation (BHF) PG/23/11344Intramural NIH HHS Z01 HL002066Intramural NIH HHS ZIA HL004601RCUK | Medical Research Council (MRC) MC_UU_00028/4U.S. Department of Health & Human Services | DHHS Office of the Secretary (OS) ZIA HL004601-35Wellcome TrustWellcome Trust (Wellcome) 220257/Z/20/Z
6 · The paper itself

Abstract

The mitochondrial membrane potential (ΔΨ

Indexed as

Membrane Potential, MitochondrialMitochondria, HeartMyocardial Reperfusion InjuryAnimalsDisease Models, AnimalHemeIsolated Heart PreparationMaleOxidation-ReductionRatsRats, Sprague-DawleySuccinic AcidHemeSuccinic Acid

Identifiers

PMID41381906
PMCPMC12708349

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.