Evidence map›Paper›PMID 41381895›Full record

ReviewDie Ophthalmologie2026

[Corneal allogeneic intrastromal ring segments].

Hyeck-Soo Son, Laura Hüfner, Gerd U Auffarth, Maximilian Friedrich, Victor A Augustin

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Die Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hyeck-Soo SonThe David J. Apple Center for Vision Research, Department of Ophthalmology, University of Heidelberg, Heidelberg, Deutschland.
Laura HüfnerThe David J. Apple Center for Vision Research, Department of Ophthalmology, University of Heidelberg, Heidelberg, Deutschland.
Gerd U AuffarthThe David J. Apple Center for Vision Research, Department of Ophthalmology, University of Heidelberg, Heidelberg, Deutschland.
Maximilian FriedrichThe David J. Apple Center for Vision Research, Department of Ophthalmology, University of Heidelberg, Heidelberg, Deutschland.
Victor A AugustinThe David J. Apple Center for Vision Research, Department of Ophthalmology, University of Heidelberg, Heidelberg, Deutschland. victor.augustin@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-6315-8484

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCorneal allogeneic intrastromal ring segments (CAIRS) are a novel minimally invasive treatment option for keratoconus. Compared to synthetic intracorneal ring segments (ICRS), they offer greater biocompatibility and customizability thanks to the use of allogeneic tissue. The aim is to regularize the curvature of the cornea and improve visual acuity with as few complications as possible.

objectiveThe aim of this review is to summarize and classify the current status of the efficacy, safety, patient selection, graft procurement and nomogram development in CAIRS. MATERIAL AND

methodsA narrative literature review of relevant original studies, meta-analyses and review articles on CAIRS was conducted, supplemented by current clinical and technical developments as well as published nomograms (e.g., Jacob, Istanbul, Awwad, Brisbane).

resultsThe literature shows consistent improvements in uncorrected and corrected distance visual acuity, Kmax and spherical equivalent. The CAIRS is associated with a low complication rate. Particularly positive results were achieved with individually customized segment geometry.

conclusionThe CAIRS offers a high degree of customization and safety while maintaining good visual efficacy. Targeted patient selection is crucial for a good outcome. In the future, artificial intelligence (AI)-based nomograms could help to further optimize planning and improve the predictability of results.

Indexed as

Corneal StromaCorneal TransplantationKeratoconusProstheses and ImplantsProsthesis ImplantationHumansTransplantation, HomologousTreatment OutcomeBiocompatibilityCorneal ectasiaIndividualizationKeratoconusPatient selection

Identifiers

PMID41381895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.