ArticleSurgical endoscopy2026
Per-oral endoscopic myotomy (POEM) results in improvement in an endoscopic score for achalasia (the CARS Score).
Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe recently developed the CARS score, an endoscopic scoring system for achalasia that is based on four common endoscopic findings of the disease (i.e., esophageal Contents, Anatomy, Resistance at the LES, and Stasis). We have shown that the CARS score performs well in predicting the presence of achalasia. Now, we aimed to find whether the CARS score improves after treatment of achalasia or EGJ outflow obstruction (EGJOO) with peroral endoscopic myotomy (POEM). MATERIALS AND
methodsWe reviewed our Center for Esophageal Diseases clinical database for patients who had POEM performed for treatment of achalasia or EGJ outflow obstruction between January 2020 and December 2022. Such patients underwent a comprehensive work up for their motility disorders including endoscopy with calculation of CARS score before and after POEM. Patients with suspected or known achalasia were instructed to be on a 1-5 day liquid diet prior to their endoscopic procedures.
resultsEighty nine patients treated with POEM meet inclusion criteria; 74 patients had achalasia (9 type 1, 46 type 2, 19 type 3), and 15 had EGJOO. The CARS score decreased significantly after POEM (3.5 vs 1.7, p < 0.01). Subset analyses of CARS subscores revealed significant reductions in contents (mean reduction 0.25, p < 0.05), resistance at the LES (mean reduction 1.3, p < 0.01) and stasis (mean reduction 0.3, p < 0.01). Patients with Type 1/2 achalasia had improvement in all CARS subscores whereas those with EGJOO/Type 3 achalasia had improvement primarily in LES resistance.
conclusionWe found significant reductions in the endoscopic CARS score in patients treated with POEM. Reductions in total CARS scores were driven primarily by improvements in the endoscopic assessment of Contents, Resistance-LES and Stasis subscores. Improvement in CARS subscores appear to differ depending on HRM diagnosis. Further studies are needed to determine whether improvement in the CARS score.
Indexed as
Identifiers
41381893What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.