ArticleMolecular psychiatry2026
Antidepressant-like effects of extinction learning as an animal model of behavioral therapy.
Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Antidepressant-like effects of extinction learning as an animal model of behavioral therapy.Molecular psychiatry · 2026Article
- Involvement of a stress-responsive orbito-striatal projection in impulsive action in male rats.The international journal of neuropsychopharmacology · 2025Article
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3 authors.
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Abstract
Exposure-based behavioral therapy, the most effective treatment for posttraumatic stress disorder (PTSD), also reduces depressive symptoms. However, neurobiological mechanisms underlying the beneficial effects of exposure-based behavioral therapy on depression remain unknown. Our lab has established fear extinction as a rat model of exposure therapy to investigate the mechanisms underlying its therapeutic behavioral effects in chronically stressed rats. In this study, we demonstrated that extinction learning reduced immobility in the forced-swim test and reversed chronic stress-induced reduction in sucrose preference. Chemogenetic inactivation of pyramidal neurons in the ventral medial prefrontal cortex (vmPFC) prevented these antidepressant-like effects of extinction. Extinction learning enhanced synaptic plasticity, reflected by enhanced optogenetically-induced long-term potentiation of mPFC responses evoked by stimulation of the afferent input from the mediodorsal thalamus (MDT). These results suggest that activity-dependent neuroplasticity induced in vmPFC by extinction learning may contribute to its antidepressant-like effects after chronic stress.
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