Evidence map›Paper›PMID 41381861›Full record

ArticleCell death and differentiation2026

cFLIP suppresses caspase-1- and MLKL-independent perinatal lethality driven by auto-processing impaired caspase-8 D387A.

Kim Newton, Katherine E Wickliffe, Allie Maltzman, Debra L Dugger, Juan Reyes, Natasha Bacarro, Søren Warming, Neha Rohatgi, Rohit Reja, Joshua D Webster and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kim Newton *Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA. knewton@gene.com.ORCID 0000-0002-4197-0340
Katherine E Wickliffe *Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Allie MaltzmanDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Debra L DuggerDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Juan ReyesDepartment of Animal Genetic Technologies, Genentech, South San Francisco, CA, USA.
Natasha BacarroDepartment of Animal Genetic Technologies, Genentech, South San Francisco, CA, USA.
Søren WarmingDepartment of Animal Genetic Technologies, Genentech, South San Francisco, CA, USA.ORCID 0000-0002-5721-0741
Neha RohatgiRoche Informatics, Hoffman-La Roche Canada, Mississauga, ON, Canada.
Rohit RejaGenentech Computational Sciences, Genentech, South San Francisco, CA, USA.
Joshua D WebsterDepartment of Pathology, Genentech, South San Francisco, CA, USA.ORCID 0000-0002-0014-1685
Vishva M DixitDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.

Funding

Genentech (Genentech, Inc.) NA
6 · The paper itself

Abstract

Death ligands, including FAS ligand (FASL) and tumor necrosis factor (TNF), trigger apoptosis by promoting caspase-8 dimerization and activation. Impaired FAS signaling causes unconventional lymphocytes to accumulate, resulting in lymphadenopathy. Although autoprocessing of caspase-8 is considered important for apoptosis, autoprocessing-deficient Casp8

Indexed as

CASP8 and FADD-Like Apoptosis Regulating ProteinCaspase 1Caspase 8Protein KinasesAnimalsApoptosisFas-Associated Death Domain ProteinHumansMiceNecroptosisNF-kappa BProtein MultimerizationReceptor-Interacting Protein Serine-Threonine KinasesSignal TransductionCASP8 and FADD-Like Apoptosis Regulating ProteinCasp8 protein, mouseCaspase 1Caspase 8Fadd protein, mouseFas-Associated Death Domain ProteinMLKL protein, mouseNF-kappa BProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouse

Identifiers

PMID41381861
PMCPMC13545278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.