Recombinant HALT-1 induces mitochondrial-associated apoptotic mechanism in HeLa cells.

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Ni(II) Complexes with Mixed Ligands, Reduced NInternational journal of molecular sciences · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lok Wenn LooDepartment of Biomedical Sciences, Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, No. 5, Jalan Universiti, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia.

Jung Shan HwangDepartment of Biomedical Sciences, Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, No. 5, Jalan Universiti, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia. hwangjs@sunway.edu.my.ORCID 0000-0002-0908-2036

Funding

Ministry of Higher Education, Malaysia FRGS/1/2018/STG03/SYUC/02/1Sunway University Internal Grant Scheme GRTIN-IGS(02)-DMS-10-2023

6 · The paper itself

Abstract

The study explored the apoptotic mechanism of Hydra actinoporin-like toxin-1 (HALT-1), an α-pore-forming toxin (α-PFT) produced by Hydra magnipapillata. α-PFT has been known to induce membrane pores in human cells upon contact, leading to the cell death. While previous research has covered HALT-1's structural, membrane binding, cytolytic, and haemolytic aspects, the detailed information on apoptotic mechanism and cell signalling pathways remain unknown. Our study confirmed previous findings of rHALT-1's dose-dependent cytotoxicity, with a CC

Indexed as

ApoptosisMitochondriaCaspase 3HeLa CellsHumansMembrane Potential, MitochondrialRecombinant ProteinsCaspase 3Recombinant ProteinsApoptotic pathway mechanismCaspasesHydra actinoporin-like toxin-1Mitochondrial depolarizationPore-forming toxin

Identifiers

PMID41381771

DOI10.1038/s41598-025-27491-y

PMCPMC12698725

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.