Evidence map›Paper›PMID 41381746›Full record

Trial reportNature medicine2026

Implementation and effectiveness of a care process to prioritize weight management in primary care: a stepped-wedge cluster-randomized trial.

Leigh Perreault, Qing Pan, Carlos Rodriguez, R Mark Gritz, Peter C Smith, E Seth Kramer, Lauren Tolle, Lauri Connelly, Caroline Tietbohl, Johnny Williams and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Leigh PerreaultDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Leigh.perreault@CUAnschutz.edu.ORCID http://orcid.org/0000-0002-1481-7535
Qing PanDepartment of Biostatistics and Bioinformatics, Milken School of Public Health, George Washington University, Washington DC, USA.
Carlos RodriguezDepartment of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
R Mark GritzDivision of Health Care Policy and Research, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-2471-8741
Peter C SmithDepartment of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
E Seth KramerDepartment of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Lauren TolleDepartment of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Lauri ConnellyDepartment of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Caroline TietbohlDepartment of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-9540-3050
Johnny WilliamsDepartment of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0009-0007-2521-4581
Jodi Summers HoltropDepartment of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Funding

PATHWEIGH: pragmatic weight management in primary careR18DK127003 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HOLTROP, JODI SUMMERS, PERREAULT, LEIGH · 2020 to 2024
$3.0M
NIDDK NIH HHS R18 DK127003U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1R18DK127003
6 · The paper itself

Abstract

Scalable, pragmatic approaches to obesity implemented in primary care have the potential to curtail population weight gain. In a stepped-wedge cluster-randomized pragmatic trial in the state of Colorado, USA, 56 primary care clinics were randomly assigned to three clusters with staggered start dates for a one-way crossover from usual care to the intervention phase. The intervention (PATHWEIGH) included three components: (1) health system primary care leadership endorsement; (2) an electronic health record-driven care process designed to prioritize, facilitate and expedite weight management; and (3) implementation strategies to support use of the care process and educate clinicians on obesity treatment. The coprimary outcomes were average patient weight loss at 6 months and weight loss maintenance from 6 months to 18 months. In total, 274,182 adults with a body mass index ≥25 kg m

Indexed as

ObesityPrimary Health CareWeight Reduction ProgramsAdultAgedBody Mass IndexColoradoElectronic Health RecordsFemaleHumansMaleMiddle AgedWeight GainWeight Loss

Identifiers

PMID41381746
PMCPMC12920108

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.