Evidence map›Paper›PMID 41381649›Full record

ArticleScientific reports2025

Association of glycemic variability with oxidative stress and AGE accumulation in type 2 diabetes.

Makoto Ohara, Noriyuki Takahashi, Nobuaki Takehana, Naoya Osaka, Hiroe Sugita, Michishige Terasaki, Yusaku Mori, Tomoyasu Fukui, Sho-Ichi Yamagishi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Makoto OharaDepartment of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa Medical University Graduate School of Medicine, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8666, Japan. s6018@med.showa-u.ac.jp.
Noriyuki TakahashiDepartment of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa Medical University Graduate School of Medicine, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8666, Japan.
Nobuaki TakehanaDepartment of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa Medical University Graduate School of Medicine, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8666, Japan.
Naoya OsakaDepartment of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa Medical University Graduate School of Medicine, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8666, Japan.
Hiroe SugitaDepartment of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa Medical University Graduate School of Medicine, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8666, Japan.
Michishige TerasakiDepartment of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa Medical University Graduate School of Medicine, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8666, Japan.
Yusaku MoriDepartment of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Antiglycation Research Section, Showa Medical University Graduate School of Medicine, Tokyo, Japan.
Tomoyasu FukuiDepartment of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa Medical University Graduate School of Medicine, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8666, Japan.
Sho-Ichi YamagishiDepartment of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa Medical University Graduate School of Medicine, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8666, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress and advanced glycation end products (AGEs) could promote vascular aging in type 2 diabetes mellitus (T2DM), but their relationship with glycemic variability remains unclear. We conducted a cross-sectional study of 68 patients with T2DM who underwent continuous glucose monitoring (CGM). Short-, intermediate-, and long-term glycemic variability were assessed using the % coefficient of variation of glucose (%CV), mean of daily differences (MODD), and HbA1c variability over the prior 2 years, respectively. Oxidative stress was measured by the diacron-reactive oxygen metabolites (d-ROMs) test, and AGE accumulation by skin autofluorescence (SAF). Multivariate analyses identified female sex, %CV, MODD, and nephropathy stage as independent correlates of d-ROMs (adjusted R

Indexed as

Blood GlucoseDiabetes Mellitus, Type 2Glycation End Products, AdvancedOxidative StressAgedCross-Sectional StudiesFemaleGlycated HemoglobinHumansMaleMiddle AgedReactive Oxygen SpeciesSkinBlood GlucoseGlycated HemoglobinGlycation End Products, AdvancedReactive Oxygen Species

Identifiers

PMID41381649
PMCPMC12808768

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.