Trial reportScientific reports2025
24-month efficacy of bioactive versus fluoride sealant for non-cavitated occlusal caries in adults: a randomized clinical trial.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05891288 (Sealing of Initial Occlusal Caries in Fissures of Permanent Molars Using Bioactive Versus Fluoride Releasing Fissure Sealants), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sealing of Initial Occlusal Caries in Fissures of Permanent Molars Using Bioactive Versus Fluoride Releasing Fissure Sealants: A Randomized Controlled Trial
Who cites it
2 citing papers in PubMed.
- Evaluation of microleakage and remineralization potential of a fissure sealant containing microcapsules on artificial enamel lesions: with and without adhesive application.BMC oral health · 2026Article
- Performance of Bioactive, Fluoride-Releasing, and Conventional Pit and Fissure Sealants: Effect of Enamel Conditioning via phosphoric acid and Er, Cr: YSGG laser in Primary Teeth.Pakistan journal of medical sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a recent suggestion by the American Academy of Pediatric Dentistry to seal initial non-cavitated carious lesions in adults. The aim of the present study was to evaluate the sealant retention and inhibition of initial carious lesion progression of the bioactive fissure sealant with SmartCap technology "Biocoat" compared to fluoride releasing fissure sealant "Clinpro sealant" over 24 months in non-cavitated occlusal carious lesions in adults. The present study is a randomized clinical trial, following a parallel group design with superiority framework and 1:1 allocation ratio. Thirty-six participants with 64 non-cavitated occlusal carious lesions were divided into two groups according to random allocation sequence (n = 32); either Biocoat (intervention) or Clinpro (control). Sealants were assessed at baseline, 12 and 24 months for retention and caries progression. Statistical analysis was performed by MedCalc 22 software for Windows. Intergroup comparison between sealants within each follow-up period was done using the Chi-Square test (p ≤ 0.05). Intragroup comparison within each intervention to assess change in clinical performance through time was performed by the Cochran's Q test (p ≤ 0.016). After 24 months, two sealants in Biocoat group and 11 sealants in Clinpro group failed due to loss of retention or caries progression. Biocoat has shown 93.75% success rate, while Clinpro has shown 65.62% success rate after 24 months. The relative risk (RR) was 0.18 (95% CI 0.04374 to 0.7558), showing 82% less risk of failure of Biocoat when compared to Clinpro sealant, and this was statistically significant (p = 0.0190). Biocoat sealant showed better retention rate and inhibition of initial carious lesion progression after 24 months when compared to fluoride releasing sealant in non-cavitated occlusal caries in adults.Clinical relevance: The present study supports the suggestion of AAPD on sealing initial carious lesions. Sealing of initial non-cavitated occlusal carious lesions is a conservative and successful approach and should be implemented in routine dental practice in adults with recent history of dental caries.Trial registration: The present clinical trial was retrospectively registered on clinicaltrials.gov on 22-05-2023 (NCT05891288).
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