Evidence map›Paper›PMID 41381597›Full record

ArticleScientific reports2025

Seminal fluid extracellular vesicles restore human sperm osmoregulation after cystic fibrosis transmembrane conductance regulator inhibition.

Sara C Pereira, Oleksandra Fomichova, Isabel Damião, Sara Oliveira, Vasco Almeida, Mariana P Monteiro, Mário Sousa, Raquel L Bernardino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sara C PereiraLaboratory of Cell Biology, Department of Microscopy, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, 4050-313, Portugal.
Oleksandra FomichovaUMIB-Unit for Multidisciplinary Research in Biomedicine, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, 4050-313, Portugal.
Isabel DamiãoCentro de Estudos de Infertilidade e Esterilidade (CEIE), Porto, 4050-345, Portugal.
Sara OliveiraCentro de Estudos de Infertilidade e Esterilidade (CEIE), Porto, 4050-345, Portugal.
Vasco AlmeidaCentro de Estudos de Infertilidade e Esterilidade (CEIE), Porto, 4050-345, Portugal.
Mariana P MonteiroUMIB-Unit for Multidisciplinary Research in Biomedicine, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, 4050-313, Portugal.
Mário Sousa *Laboratory of Cell Biology, Department of Microscopy, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, 4050-313, Portugal.
Raquel L Bernardino *UMIB-Unit for Multidisciplinary Research in Biomedicine, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, 4050-313, Portugal. rlbernardino@icbas.up.pt.ORCID 0000-0002-1941-6634

Funding

Fundação para a Ciência e a Tecnologia 10.54499/2021.05487.BDFundação para a Ciência e a Tecnologia UID/215/2025
6 · The paper itself

Abstract

Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel that promotes the exchange of chloride (Cl

Indexed as

Cystic Fibrosis Transmembrane Conductance RegulatorExtracellular VesiclesOsmoregulationSemenSpermatozoaCalciumChloridesGlycerolHumansMaleSperm MotilityCalciumCFTR protein, humanChloridesCystic Fibrosis Transmembrane Conductance RegulatorGlycerolCFTRExtracellular vesiclesOsmoregulationSeminal fluid

Identifiers

PMID41381597
PMCPMC12698702

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.