ArticleNature communications2025
Lithium exposure causes ferroptosis to induce unexplained miscarriage through non-canonical MBOAT1 pathway.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- m6A-Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Thermodynamic Stability Boundary of Hygroscopic Salt-Embedded Composite Materials for Atmospheric Water Harvesting.Advanced materials (Deerfield Beach, Fla.) · 2026Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High incidence of unexplained miscarriage (UM) limits global human reproduction. Lithium (Li) batteries are widely used but rarely recycled, causing Li to spread into environments and enter human body. Notably, the healthy effects of Li exposure on UM are rarely explored. Herein, higher serum Li levels, villous tissue ferroptosis, and UM are associated. Exposure to high levels of Li causes placental ferroptosis to induce mouse miscarriage. Li exposure down-regulates ER levels to suppress ER-mediated METTL1 and MBOAT1 transcription, and also suppresses METTL1-mediated m7G modification on MBOAT1 mRNA to reduce MBOAT1 mRNA stability. Therefore, Li exposure causes ferroptosis in a GPX4-independent manner. Supplement with murine Mboat1 suppresses placental ferroptosis and relieves miscarriage in LiCl-exposed mouse model. This study discovers health risks and pathogenesis of Li exposure-induced UM, reveals potential biological targets, and also proposes an important Li exposure theme in energy-environment-health field, which deserves attention by global governments and enterprises.
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