Evidence map›Paper›PMID 41381565›Full record

ArticleNature communications2025

A B cell-IgA-epithelial axis enhances antitumor immunity and improves outcome in HPV-associated penile squamous cell carcinoma.

Tao Tao, Lianbang Zhu, Deyun Shen, Jiayang Zhang, Panrui Zhang, Zhixi Gu, Dan Cao, Jun Xiao, Wen Pan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tao Tao *Department of Urology, The First Affiliated Hospital of USTC, Centre for Leading Medicine and Advanced Technologies of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Lianbang Zhu *Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Deyun Shen *Department of Urology, The First Affiliated Hospital of USTC, Centre for Leading Medicine and Advanced Technologies of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Jiayang ZhangKey Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Panrui ZhangKey Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Zhixi GuKey Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Dan CaoKey Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0002-9179-3311
Jun XiaoDepartment of Urology, The First Affiliated Hospital of USTC, Centre for Leading Medicine and Advanced Technologies of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. ixiaojun@ustc.edu.cn.
Wen PanKey Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. wenpan@ustc.edu.cn.ORCID http://orcid.org/0000-0002-8866-6354

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Penile squamous cell carcinoma (PSCC) is a rare, aggressive malignancy, with HPV driving approximately 50% of cases and correlating with improved outcomes. In this study, we perform single-cell RNA sequencing on tumor microenvironment (TME) cells from 23 treatment-naive PSCC patients, including 11 cases reported previously, and validate our findings in a larger cohort of 85 patients. Our analysis reveals significant immune cell infiltration in PSCC, with HPV

Indexed as

B-LymphocytesCarcinoma, Squamous CellImmunoglobulin APapillomavirus InfectionsPenile NeoplasmsAnimalsEpithelial CellsHumansLymphocytes, Tumor-InfiltratingMaleMiceMiddle AgedReceptors, Polymeric ImmunoglobulinSingle-Cell AnalysisTumor MicroenvironmentImmunoglobulin AReceptors, Polymeric Immunoglobulin

Identifiers

PMID41381565
PMCPMC12816729

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.