ArticleNPJ science of food2025
Haematococcus pluvialis ameliorates renal fibrosis by restoring mitophagy via PINK1-Parkin-p62-LC3 signaling.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Mechanistic Insights into Aldose Reductase-Dependent Modulation of Hypoxia-Inducible Factor-1α in Promoting Renal Fibrosis.Cell biochemistry and biophysics · 2026Article
- Synergistic Application of Cytidine Monophosphate and Sodium Chloride for Enhanced Co-Production of Astaxanthin and Fatty Acids inMarine drugs · 2026Article
- Gut microbiota-associated N-Acetyl-L-leucine mediates fructose-induced hyperuricemia via the P300-URAT1 pathway.NPJ science of food · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Renal fibrosis is a key pathological process of chronic kidney disease (CKD) and is associated with epithelial-mesenchymal transition (EMT) and mitochondrial dysfunction. Haematococcus pluvialis (H. pluvialis), a unicellular green alga, is rich in natural antioxidants like astaxanthin and unsaturated fatty acids. This study aimed to explore the renal protective effects and the potential mechanisms of H. pluvialis in vivo and in vitro. The bioinformatics analysis combined with in vivo and in vitro studies revealed that H. pluvialis attenuated renal fibrosis by restoring mitophagy and reversing EMT. For in vivo experiments, H. pluvialis reduced renal ECM deposition and improved renal injury in the unilateral ureteral obstruction (UUO) rats. RNA-seq analysis and in vitro studies showed that H. pluvialis reversed the TGF-β1-induced EMT in HK-2 cells and improved mitochondrial energy metabolism. Immunofluorescence and molecular docking results suggested that H. pluvialis, especially astaxanthin and trans-3-indoleacrylic acid in it, restored mitophagy via PINK1-Parkin-p62-LC3 signaling and reduced pro-fibrotic factor secretion in HK-2 cells. This study supports the development of H. pluvialis as a functional food for CKD management, providing a new strategy to ameliorate renal fibrosis.
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Registered trials
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