Evidence map›Paper›PMID 41381544›Full record

ArticleNPJ microgravity2025

Effect of calcium oxalate microcrystals on kidney proximal tubule epithelial cell gene expression in microgravity.

Kendan Jones-Isaac, Catherine K Yeung, Jacelyn Bain, Kevin Lidberg, Jade Yang, Lu Wang, James MacDonald, Theo Bammler, Kenneth E Thummel, Megan Corn and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Kendan Jones-IsaacDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Catherine K YeungDepartment of Pharmacy, University of Washington, Seattle, WA, USA. cathyy@uw.edu.
Jacelyn BainDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Kevin LidbergDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Jade YangDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Lu WangDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
James MacDonaldDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Theo BammlerDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Kenneth E ThummelDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Megan CornDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Micaela Vela RuizDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Stefanie CountrymanBioServe Space Technologies, University of Colorado, Colorado, CO, USA.
Paul KoenigBioServe Space Technologies, University of Colorado, Colorado, CO, USA.
Henning H MannHM Bioconsulting, Seattle, WA, USA.
Jonathan HimmelfarbKidney Research Institute, University of Washington, Seattle, WA, USA.
Edward J KellyDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA. edkelly@uw.edu.

Funding

Environmetal Pathology/Toxicology Training ProgramT32ES007032 · NIEHS · UNIVERSITY OF WASHINGTON · PI FAUSTMAN, ELAINE M, ROSENFELD, MICHAEL E · 1985 to 2023
$10.7M
Using iPSCs to model patient outcomes in nephrotic syndromeUH3TR000504 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN · 2014 to 2016
$6.1M
A Microphysiological System for Kidney Disease Modeling and Drug Efficacy TestingUG3TR002158 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN · 2017 to 2018
$2.9M
Effects of microgravity on the structure and function of proximal and distal tubule MPSUH3TR002178 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN, KELLY, EDWARD J · 2019 to 2020
$842k
Effects of microgravity on the structure and function of proximal and distal tubule MPSUG3TR002178 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN, KELLY, EDWARD J · 2017 to 2018
$769k
Center for the Advancement of Science in Space UG3TR002178Center for the Advancement of Science in Space UH3TR002178NCATS NIH HHS UG3 TR002158NCATS NIH HHS UG3 TR002178NCATS NIH HHS UG3TR002178NCATS NIH HHS UH3 TR000504NCATS NIH HHS UH3 TR002178NCATS NIH HHS UH3TR002178NIEHS NIH HHS P30ES00703NIEHS NIH HHS T32 ES007032NIEHS NIH HHS T32ES007032Science Mission Directorate 80JSC020F0019
6 · The paper itself

Abstract

We evaluated the impact of spaceflight on a microphysiologic model of calcium oxalate (CaOx) kidney stone disease. Proximal tubule epithelial cells cultured as confluent microtubules were exposed to CaOx crystals with or without potassium citrate (a potential countermeasure) to determine the impact on gene expression. Nine genes were differentially expressed in response to CaOx crystal exposure during spaceflight. This project presents the use of microgravity as a unique environment to study kidney pathophysiology.

Identifiers

PMID41381544
PMCPMC12775050

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.