Evidence map›Paper›PMID 41381538›Full record

ArticleNature communications2025

An antimicrobial daptide from human skin commensal Staphylococcus hominis protects against skin pathogens.

Amber Nguyen, Zoie L Bunch, Ingrid Y Martinez-Aldino, Manuel Rangel-Grimaldo, Uday Tak, John C Thorstenson, Morgan M Severn, Teruaki Nakatsuji, Richard L Gallo, Tyler N Graf and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Amber Nguyen *Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-2768-8143
Zoie L Bunch *Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.ORCID http://orcid.org/0000-0002-8632-4422
Ingrid Y Martinez-AldinoDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.
Manuel Rangel-GrimaldoDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.
Uday TakDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.
John C ThorstensonDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0009-0005-9054-7724
Morgan M SevernDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Teruaki NakatsujiDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.
Richard L GalloDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.
Tyler N GrafDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.ORCID http://orcid.org/0000-0003-4145-2815
Nicholas H OberliesDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.ORCID http://orcid.org/0000-0002-0354-8464
Jonathan R ChekanDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.ORCID http://orcid.org/0000-0003-4651-0594
Nadja B CechDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. alexander.horswill@cuanschutz.edu.

Funding

Skin microbes and development of allergic diseaseR01AI192662 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L, KNIGHT, ROB · 2025 to 2025
$5.2M
Quorum sensing, diversity and skin inflammationR01AI153185 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GALLO, RICHARD L, HORSWILL, ALEXANDER R · 2020 to 2024
$3.2M
Bioinformatic Guided Discovery and Characterization of New RiPP Natural ProductsR35GM147439 · NIGMS · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI Jonathan Rodi Chekan · 2022 to 2026
$1.8M
Predoctoral Training: Innovative Technologies for Natural Products and Integrative Medicine ResearchT32AT008938 · NCCIH · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI Nadja B Cech, Jonathan Rodi Chekan · 2016 to 2026
$1.6M
NCCIH NIH HHS T32 AT008938NIAID NIH HHS R01 AI153185NIAID NIH HHS R01 AI192662NIGMS NIH HHS R35 GM147439U.S. Department of Health & Human Services | NIH | National Center for Complementary and Integrative Health (NCCIH) T32AT008938U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI153185U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM147439
6 · The paper itself

Abstract

Coagulase-negative staphylococci are dominant human skin colonizers, producing natural products that shape the community and prevent pathogen colonization. The molecular mechanisms by which these natural products mediate interbacterial competition are not fully understood. Here, we identify a plasmid-borne daptide bacteriocin (hominicin) from a human skin isolate of Staphylococcus hominis, which features an unusual N

Indexed as

Anti-Bacterial AgentsBacteriocinsSkinStaphylococcal Skin InfectionsStaphylococcus hominisAnimalsFemaleHumansMiceMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsBacteriocins

Identifiers

PMID41381538
PMCPMC12749797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.