Evidence map›Paper›PMID 41381524›Full record

ArticleNature communications2025

Lypd6b depletion promotes CD8

Ting Liu, Fanxin Zeng, Zuyin Li, Leirong Cheng, Xuanxuan Yan, Haiqiang Chen, Qin Liu, Xue Li, Zhao Li, Jiaheng Yao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ting Liu *The College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, China.
Fanxin Zeng *Department of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan, China.ORCID http://orcid.org/0000-0002-7337-4463
Zuyin Li *Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China.
Leirong Cheng *The College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, China.
Xuanxuan YanThe College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, China.
Haiqiang ChenThe College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, China.
Qin LiuDepartment of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan, China.
Xue LiDepartment of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan, China.
Zhao LiDepartment of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China.
Jiaheng YaoThe College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, China.
Dan XuNational Institute of Biological Sciences, Beijing, China.
Zhinan ChenSchool of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.ORCID http://orcid.org/0000-0001-5512-4623
Fengchao WangNational Institute of Biological Sciences, Beijing, China. wangfengchao@nibs.ac.cn.ORCID http://orcid.org/0000-0002-3595-2859
Jun WangDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA. jun.wang@nyulangone.org.
Jinhua ZhangThe College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, China. zhangjh@bjtu.edu.cn.ORCID http://orcid.org/0000-0001-8957-8893

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphocyte antigen-plasminogen activator urokinase receptor domain-containing protein 6B (Lypd6b) is a newly identified molecule associated with neuromodulation. However, the role of Lypd6b in regulating the tumor microenvironment and its impact on CD8

Indexed as

CD8-Positive T-LymphocytesColorectal NeoplasmsAnimalsCell Line, TumorFemaleGlycolysisHumansLymphocytes, Tumor-InfiltratingMaleMetabolic ReprogrammingMiceMice, Inbred C57BLMice, KnockoutOxidative PhosphorylationProgrammed Cell Death 1 ReceptorSignal TransductionPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorTOR Serine-Threonine Kinases

Identifiers

PMID41381524
PMCPMC12820146

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.