Evidence map›Paper›PMID 41381494›Full record

ArticleNature communications2025

C1q drives neural stem cell quiescence by regulating cell cycle and metabolism through BAI1.

Katja M Piltti, Anita Lakatos, Francisca Benavente-Perez, Zeina H Elrachid, Aileen A Nava, Nathaniel T Addonizio, Victoria Nguyen, Atena Zahedi, Wei A Song, Xiyu Chen and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Katja M PilttiSue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA. kpiltti@uci.edu.ORCID http://orcid.org/0000-0002-9773-0442
Anita Lakatos *Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0001-8973-186X
Francisca Benavente-Perez *Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA.
Zeina H ElrachidSue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0009-0005-9033-0242
Aileen A NavaSue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-2053-6713
Nathaniel T AddonizioSue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0009-0005-2375-730X
Victoria NguyenCalifornia State University Long Beach, Long Beach, CA, USA.ORCID http://orcid.org/0009-0007-4659-8393
Atena ZahediSue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-1005-9845
Wei A SongCalifornia State University Fullerton, Fullerton, CA, USA.ORCID http://orcid.org/0000-0001-7797-9163
Xiyu ChenSue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0009-0007-6314-5468
Josh DavidSue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0009-0008-4099-5598
Andreina PortilloCalifornia State University Fullerton, Fullerton, CA, USA.
Ayla O Manughian-PeterCalifornia State University Long Beach, Long Beach, CA, USA.
Andrea N RodriguezCalifornia State University San Bernardino, San Bernardino, CA, USA.
Andrea AnzaloneSue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA.
Catherine M CahillDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-6936-5524
Aileen J AndersonSue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA. aja@uci.edu.ORCID http://orcid.org/0000-0002-8203-8891

Funding

Institute for Clinical and Translational ScienceUM1TR004927 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAN M COOPER, Eric J. Vilain · 2024 to 2026
$12.2M
UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARLEY IAN KORNBLUM · 2020 to 2026
$9.6M
Elucidating the pathogenic mechanisms by which KAT6A mutations alter human in vitro neurodevelopmentF31NS141668 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aileen Anai Nava · 2025 to 2026
$84k
NCATS NIH HHS UM1 TR004927NICHD NIH HHS P50 HD103557NINDS NIH HHS F31 NS141668Wings for Life (Wings for Life Research Foundation) WFL-US-01/18
6 · The paper itself

Abstract

C1q levels in the CNS are elevated by inflammation and neurovascular trauma, yet the consequence of this increase for neural stem cell (NSC) regeneration response remain unknown. We have recently identified C1q receptor candidates that regulate NSC behavior. One of these is Brain Angiogenesis Inhibitor 1 (BAI1, ADGRB1), which has no previously discovered role in NSC. Here, we show that C1q acts in a BAI1-dependent manner to modulate NSC quiescence via two parallel mechanisms. First, negative regulation of MDM2, driving cell cycle suppression through p53. Second, endocytic internalization of C1q-BAI1-complex, driving regulation of p32 (C1qBP) and metabolic reprogramming towards aerobic glycolysis. We validated the biological significance of BAI1 in a male hNSC line in vivo using a female mouse model of acute spinal cord injury (SCI). These findings are relevant for a multiplicity of CNS disorders, and illuminate complex connections between C1q, cell cycle, and metabolism. Together, these data provide valuable insight into C1q-mediated regulation of NSC transition between activation and quiescence, processes fundamental for tissue development and repair.

Indexed as

Cell CycleComplement C1qNeural Stem CellsAnimalsFemaleHumansMaleMiceMice, Inbred C57BLSpinal Cord InjuriesTumor Suppressor Protein p53Complement C1qTumor Suppressor Protein p53

Identifiers

PMID41381494
PMCPMC12738564

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.