ArticleNature communications2025
Layer 5 myelination gates corticothalamic coincidence detection.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Transcriptional Heterogeneity of Oligodendrocytes: Molecular Basis of Diversity Across Development, Brain Regions, and Neurological Diseases.Neurology international · 2026Review
- A computational roadmap to activity-dependent myelination.Frontiers in computational neuroscience · 2026Article
- Extracellular vesicles for Alzheimer's disease therapy: mechanisms, engineering strategies, and clinical translation.Extracellular vesicles and circulating nucleic acids · 2026Review
- Delayed transcallosal conduction to the lesioned sensorimotor cortex in multiple Sclerosis: A combined TMS 7 T-MRI study.NeuroImage. Clinical · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
Myelin is essential for the rapid conduction of action potentials (APs) but its role in long-range processing of disparate inputs remains unclear. Here, using a cell-type-specific approach we recorded optogenetically evoked pyramidal neuron responses via in vivo juxtacellular patch-clamp and Neuropixels probes, tracking spike transmission from layer 5 (L5) to the posteromedial thalamic nucleus (POm) in the mouse. Cuprizone-induced demyelination caused millisecond-scale delays, increased temporal jitter and impaired transmission of high-frequency AP bursts. Computational modeling of the saltatory propagation from L5 to POm revealed that myelin loss from neocortical internodes acts as a low-pass filter, impeding high-frequency spikes within the burst. Finally, pairing optogenetic stimulation with whisker input showed that intact myelination is crucial for coincidence detection in the thalamus. These findings suggest that the continuous myelin pattern of L5 axons not only speeds conduction but also enables precise temporal integration of sensory and cortical signals across long-range pathways.
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