ArticleNature communications2025
Programmable Assembly of Multistranded Helices in Water.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Sequence-specific conformational changes underpin essential biological processes, from information storage to energy transduction, but are difficult to replicate in synthetic systems. Here, we present a simple approach to encode in the primary sequence of molecular strands all the information required to govern both the formation and dynamic behavior of multistranded helices. We demonstrate that the sequence of oligo(m-phenylene ethynylene) strands composed of hydrophobic phenylene and charged pyridinium residues reliably direct the formation of either a single structure (e.g., a double helix) or dynamic assemblies (e.g., double and triple helices in exchange). In the latter case, transitions between different helical states can be controlled by concentration, temperature, or by the presence of anionic molecules. This minimal yet versatile design strategy lays the groundwork for the construction of adaptive supramolecular systems with programmable structure and function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.