Evidence map›Paper›PMID 41381461›Full record

ArticleNature communications2025

Schisantherin A interacts with gut bacteria to stimulate adipose tissue thermogenesis in obese mice via a TGR5‒p-CREB‒STAT6 signaling pathway.

Xunjiang Wang, Xu Wang, Shenglan Yu, Luyao Huang, Qiongwen Xue, Xinru Yang, Zixuan Wang, Wenyuan Lin, Yaping Jiang, Ying Xu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Bile acid signaling in health and disease.Molecular biomedicine · 2026
    Review
  2. Article
  3. Foods (Basel, Switzerland) · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xunjiang Wang *State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID http://orcid.org/0009-0006-4973-3039
Xu Wang *State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID http://orcid.org/0009-0004-6224-3558
Shenglan Yu *State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Luyao Huang *State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Qiongwen XueState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xinru YangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zixuan WangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wenyuan LinState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yaping JiangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ying XuSuzhou PANOMIX Biomedical Tech Co., Ltd., Suzhou, Jiangsu, China.
Qi LiaoState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-7109-6471
Lihua JinDepartment of Diabetes Complications and Metabolism, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA.ORCID http://orcid.org/0000-0002-2685-6048
Zhengtao WangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID http://orcid.org/0000-0003-2797-4625
Feng TaoEndocrinology Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. taofeng@shutcm.edu.cn.ORCID http://orcid.org/0000-0003-1214-6800
Li YangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China. yl7@shutcm.edu.cn.ORCID http://orcid.org/0000-0002-5484-0895
Wendong HuangDepartment of Diabetes Complications and Metabolism, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA. whuang@coh.org.ORCID http://orcid.org/0000-0003-3735-9466
Lili DingState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Key Laboratory of Compound Chinese Medicines and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China. liliding@shutcm.edu.cn.ORCID http://orcid.org/0000-0002-4831-3300

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global epidemic of obesity challenges the scientific and medical communities to find different treatments. Schisantherin A (Sin A), a natural compound isolated from Schisandra chinensis (Turcz.), reduces the abundance of bile salt hydrolase-producing gut bacteria in obese mice, leading to accumulation of specific conjugated bile acids (CBAs). These elevated CBAs activate a signaling axis containing Takeda G protein-coupled receptor 5, phosphorylated cAMP-responsive element binding protein 1, and signal transducer and activator of transcription 6 (TGR5-p-CREB-STAT6), wherein CREB directly binds to the STAT6 promoter. Sin A-induced STAT6 activation promoted M2-like macrophages polarization to secret slit guidance ligand 3 (SLIT3), which consequently stimulated norepinephrine release in sympathetic neurons and induced thermogenesis in adipose tissue. This study thus identifies a pathway by which Sin A interacts with gut bacteria to stimulate CBA-mediated beiging of white adipose tissue, highlighting a promising natural product-based strategy for obesity treatment.

Indexed as

Adipose TissueDioxolesGastrointestinal MicrobiomeLignansObesityReceptors, G-Protein-CoupledThermogenesisAnimalsBile Acids and SaltsCyclic AMP Response Element-Binding ProteinMacrophagesMaleMiceMice, Inbred C57BLMice, ObeseSignal TransductionBile Acids and SaltsCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinDioxolesGpbar1 protein, mouseLignansReceptors, G-Protein-Coupled

Identifiers

PMID41381461
PMCPMC12800289

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.