ArticleNature communications2025
Gut Phage Biobank: a collection of bacteriophages targeting human commensal bacteria.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Mechanisms and Application of Bacteriophages in Regulating Intestinal Health of Livestock and Poultry.MicrobiologyOpen · 2026Review
- A genomic catalog of the mouse gut virome reveals features associated with ageing.Nature communications · 2026Article
- Isolation of novel phages from a resistant Dorea longicatena strain reveals genes associated with phage resistance.Npj viruses · 2026Article
- From dysbacteriosis to ecological remodeling: A new breakthrough in microbial treatment of inflammatory bowel disease.iScience · 2026Review
- Gut virome-microbiome interactions across hosts and environments.NPJ biofilms and microbiomes · 2026Article
- Strain Diversity in the Human Microbiome: Personal Variation, Pathobionts, Therapeutics, and Methodological Challenges.Microorganisms · 2026Review
- The gut virome and regulatory T cell axis in health and systemic disease.Microbiome research reports · 2026Review
- Isolation and characterization of seven phages infecting gutGut microbes reports · 2026Article
- Phage biobanks as enabling infrastructure for precision phage therapy in the era of antimicrobial resistance.Frontiers in antibiotics · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The scarcity of cultivated gut bacteriophages hinders gut microbial research and application. Here we report the establishment and characterization of a Gut Phage Biobank (GPB) ( https://db.cngb.org/genomics/datasets/GDS0000055 ) through a systematic isolation workflow and containing 104 isolates that target abundant or disease-associated gut bacteria. Genomic analysis reveals high diversity among these phages, and key genes of phage-bacteria interactions. The infection matrix demonstrates high host-specificity and varying infectivity of these phages under different conditions, unveiling phage-bacteria interaction mechanisms. In-depth characterization of the phages targeting obligate anaerobes uncovers a previously undescribed family and four previously undescribed genera, one of which is more prevalent than the well-known crAss-like phages globally except in Eurafrica. Cohort analysis reveals a higher prevalence of Mediterraneibacter and Dorea and a lower prevalence of Mediterraneibacter phages in Asian disease population. In vitro and in vivo evidence of phage inhibiting Dorea highlight the potential of phages in disease intervention. This biobank represents a valuable resource for advancing gut microbial research and holds promise for manipulating microbiomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.