Evidence map›Paper›PMID 41381410›Full record

ArticleACS infectious diseases2026

Bacterial Carbonic Anhydrase Inhibitor CAI0019 Demonstrates Efficacy in

Nader S Abutaleb, Katrina J Holly, Carolyn K Metcalfe, Ahmed A Abouelkhair, Prabhakara R Tharra, Annadka Shrinidhi, Abdallah S Abdelsattar, Victoria Burgo, Glory Melotte, Tomi Akin-Olabiyi and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Nader S AbutalebDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.
Katrina J HollyBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.
Carolyn K MetcalfeBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-9304-8681
Ahmed A AbouelkhairDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.ORCID 0000-0001-9937-742X
Prabhakara R TharraBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.
Annadka ShrinidhiBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0003-1022-617X
Abdallah S AbdelsattarDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.
Victoria BurgoDuchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States.
Glory MelotteDuchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States.
Tomi Akin-OlabiyiDuchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States.
Sean KnoblauchDuchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States.
Ramanujam RamaswamyDuchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0001-7448-6574
Che WoodsonDuchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States.
Venkatesh P ThirumalaikumarPurdue Proteomics Facility, Bindley Bioscience Center, Purdue University, West Lafayette, Indiana 47907, United States.
J Alejandra RodriguezDepartment of Biological Sciences, Purdue University, West Lafeyette, Indiana 47907, United States.
Franklin J YeoDepartment of Biological Sciences, Purdue University, West Lafeyette, Indiana 47907, United States.
Olivia C SnellBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.
Alessio NocentiniDepartment of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino 50122, Italy.ORCID 0000-0003-3342-702X
Anitha SundararajanDuchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States.
Matthew R OlsonDepartment of Biological Sciences, Purdue University, West Lafeyette, Indiana 47907, United States.
Claudiu T SupuranDepartment of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino 50122, Italy.ORCID 0000-0003-4262-0323
Mohamed N SeleemDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.ORCID 0000-0003-0939-0458
Daniel P FlahertyBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-8305-0606

Funding

Repurposing novel selective drugs for treatment and decolonization of vancomycin resistant enterococciR01AI148523 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Daniel Patrick Flaherty, Mohamed Seleem · 2019 to 2026
$4.2M
Development of novel anti-Neisseria gonorrhoeae therapeutic agentsR01AI153264 · NIAID · PURDUE UNIVERSITY · PI FLAHERTY, DANIEL PATRICK · 2022 to 2025
$3.1M
NIAID NIH HHS R01 AI148523NIAID NIH HHS R01 AI153264
6 · The paper itself

Abstract

Vancomycin-resistant enterococci are multidrug-resistant bacteria that as of 2021 continue to pervade the U.S. healthcare system as the second-most prevalent source of healthcare-acquired infections behind

Indexed as

Anti-Bacterial AgentsCarbonic Anhydrase InhibitorsEnterococcus faeciumGastrointestinal MicrobiomeGram-Positive Bacterial InfectionsPeritonitisSepsisAcetazolamideAnimalsCarbonic AnhydrasesDisease Models, AnimalMiceAcetazolamideAnti-Bacterial AgentsCarbonic Anhydrase InhibitorsCarbonic Anhydrasesanimal modelsantibioticscarbonic anhydrase inhibitorchemoproteomicsenterococcusmicrobiomepharmacokinetics

Identifiers

PMID41381410
PMCPMC12862769

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.