ArticleUltrasound in medicine & biology2026
Analysis of Color Doppler Twinkling on Breast Biopsy Markers With Hydrostatic Overpressurization and Micro-CT Imaging.
Article in Ultrasound in medicine & biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Does Color Doppler Twinkling Change Between Ultrasound Platform Generations? - A Comparison Using Breast Biopsy Markers.Academic radiology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivePrevious development of a breast biopsy marker that can be readily detected using color Doppler twinkling has been reported, but the cause of twinkling remains unclear. The objective is to better understand the mechanism for twinkling by exploring the effects of microbubbles on the surfaces of markers that twinkle compared to those that do not.
methodsTwinkling metallic clinical markers and twinkling polymethyl methacrylate (PMMA) markers were evaluated in a pressure chamber. The hydrostatic pressure around the markers was increased from 0 to 1000 psi. To evaluate the effects of internal and external structures on twinkling, micro-CT scans were conducted to analyze the internal voids and surface roughness of the markers. A low-twinkling PMMA sample and a non-twinkling metal rod were also tested.
resultsTwinkling markers exhibited decreased twinkling as the hydrostatic pressure increased. PMMA markers mixed for approximately 75% of the time required to reach the hardening phase of the polymerization reaction exhibited the highest twinkling signals under increased pressure. Internal voids were found to have no correlation with twinkling. Samples with higher surface roughness values (S
conclusionThese results support oscillating microbubbles on surfaces as a cause of twinkling. Prior work connecting surface roughness to twinkling is, hence, corroborated by the microbubbles present on rougher surfaces.
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Registered trials
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