ArticleThe European respiratory journal2026
Low mortality and favourable outcome in lung volume reduction surgery for different emphysema morphologies.
Article in The European respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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11 authors.
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Abstract
backgroundA quarter of a century after the National Emphysema Treatment Trial (NETT), lung volume reduction surgery (LVRS) remains an underused procedure with the notion of high mortality and morbidity, mainly recommended for upper lobe predominant heterogeneous emphysema. With advances in patient selection, minimally invasive surgery and improved recovery, this perception may be outdated. This study evaluates 5-year single-centre outcome, including patients beyond traditional NETT criteria (non-upper lobe and non-heterogeneous morphology).
methodsThis prospective study included all consecutive LVRS procedures (August 2019 to July 2024). Surgical, functional and quality of life outcomes (COPD Assessment Test (CAT) and St George's Respiratory Questionnaire (SGRQ)) were analysed at 3 and 6 months, and then annually up to 3 years. Subanalysis compared markedly
results223 procedures were performed in 191 patients with baseline median (interquartile range) forced expiratory volume in 1 s (FEV
conclusionsThis study demonstrates that LVRS performed in a specialised centre results in exceptionally low mortality and morbidity, and meaningful clinical and functional improvement, supporting broader indications beyond classical NETT criteria.
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