Observational studyBMJ open2025
Drug-related pressure ulcers in hospitalised patients: a multicentre retrospective study in Japan identifying high-risk medications and patient characteristics.
Observational study in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
22 authors.
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Abstract
objectivesTo characterise patient and medication-related patterns observed in drug-related pressure ulcers (DRPUs) and provide descriptive findings that may support future consensus-building.
designMulticentre retrospective observational study.
setting20 hospitals across Japan participated in the study with hospital pharmacists specialised in PU care.
participantsA total of 1113 hospitalised patients with existing PUs were included and classified into three groups (definite, probable and no-possibility of DRPUs) based on predefined criteria. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was the description of medication-related characteristics observed in each DRPU classification group, including polypharmacy, initiation of new medications and dose adjustments. Secondary outcomes included differences in ulcer characteristics and functional status across DRPU categories.
resultsThe definite group (n=128, 11.5%) showed a significantly higher prevalence of polypharmacy (83.6% vs 71.1% in the no-possibility group, p<0.01), frequent medication adjustments (76% vs 46%, p<0.01), use of antipsychotic medications (34% vs 10%, p<0.01) and missed doses of anti-Parkinson's drugs (8% vs 3%, p<0.01). These patients were less frequently bedridden despite having PUs.
conclusionsMedication-related characteristics such as polypharmacy, initiation of new medications, dose modifications and use of antipsychotics were more frequently observed in the definite DRPU group. These descriptive findings may help characterise the clinical patterns of DRPUs and may inform future hypothesis generation.
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