ArticleCancer letters2026
Fgl2-knockout tumor cells serve as a vaccine inducing long-duration brain-resident memory T cells that reject subsequent intracranial tumor cell challenges.
Sheng Zhang, Yining Jin, Zhiliang Jia, Xueqing Xia, Yang Li, Qi Wang, Jing Wang, Jian Wang, Joya Chandra, Gregory K Friedman and 1 more
Abstract read
In one paragraphArticle in Cancer letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Sheng ZhangDepartment of Pediatrics Research, The University of Texas MD Anderson Cancer Center, USA.
Yining JinDepartment of Pediatrics Research, The University of Texas MD Anderson Cancer Center, USA.
Zhiliang JiaDepartment of Pediatrics Research, The University of Texas MD Anderson Cancer Center, USA.
Xueqing XiaDepartment of Pediatrics Research, The University of Texas MD Anderson Cancer Center, USA.
Yang LiDepartment of Pediatrics Research, The University of Texas MD Anderson Cancer Center, USA.
Qi WangDepartment of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, USA.
Jing WangDepartment of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, USA.
Jian WangDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, USA.
Joya ChandraDepartment of Pediatrics Research, The University of Texas MD Anderson Cancer Center, USA.
Gregory K FriedmanDepartment of Pediatrics Research, The University of Texas MD Anderson Cancer Center, USA.
Shulin LiDepartment of Pediatrics Research, The University of Texas MD Anderson Cancer Center, USA. Electronic address: sli4@mdanderson.org.
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8MFgl2 neutralizing therapy for inducing tumor specific brain resident immune memory against CNS tumor relapseR01NS122857 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HEIMBERGER, AMY BETH, LI, SHULIN · 2021 to 2025
$2.9MFunctional Proteomics by Reverse Phase Protein Array in CancerR50CA221675 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LU, YILING · 2017 to 2021
$726kNCI NIH HHS P30 CA016672NCI NIH HHS R50 CA221675NINDS NIH HHS R01 NS122857
6 · The paper itselfAbstract
The failure to prevent brain tumors, including both recurrent primary and metastatic brain tumors, is the primary cause of patients' mortality. We developed a novel whole tumor-cell vaccine to rapidly induce long-duration brain-resident memory T (T
Indexed as
Brain NeoplasmsCancer VaccinesImmunologic MemoryMemory T CellsAnimalsBrainCell Line, TumorFemaleHumansMiceMice, Inbred C57BLMice, KnockoutCancer VaccinesBrain tumorsCD47Fibrinogen-like protein 2ImmunotherapyResident memory T cells
Identifiers
PMID41380903
PMCPMC13359019
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