Evidence map›Paper›PMID 41380732›Full record

ArticleThe Thoracic and cardiovascular surgeon2026

Surgical Myectomy with Anterior Mitral Leaflet Extension Versus Isolated Myectomy in Patients with Hypertrophic Obstructive Cardiomyopathy.

Tijn J P Heeringa, Marieke Hoogewerf, Romy Hegeman, Dimitri van Wylick, David Stecher, Maarten Jan Cramer, Giulia De Zan, Yvonne Koop, Ronald C A Meijer, Nicolaas P A Zuithoff and 5 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Thoracic and cardiovascular surgeon, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tijn J P HeeringaDepartment of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.ORCID 0009-0006-2567-9429
Marieke HoogewerfDepartment of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
Romy HegemanDepartment of Cardiothoracic Surgery, St Antonius Hospital, Nieuwegein, Utrecht, The Netherlands.
Dimitri van WylickDepartment of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
David StecherDepartment of Cardiothoracic Surgery, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.
Maarten Jan CramerDepartment of Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Giulia De ZanDepartment of Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Yvonne KoopDepartment of Cardiovascular Epidemiology, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands.
Ronald C A MeijerDepartment of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
Nicolaas P A ZuithoffDepartment of Cardiovascular Epidemiology, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands.
Pim van der HarstDepartment of Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Marco GuglielmoDepartment of Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Ilonca VaartjesDepartment of Cardiovascular Epidemiology, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands.
Mostafa M MokhlesDepartment of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
Niels P van der KaaijDepartment of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study evaluated the echocardiographic parameters and complication rates of surgical myectomy with concomitant anterior mitral leaflet extension (SM + AMLE) and isolated SM in hypertrophic obstructive cardiomyopathy (HOCM) patients. Methods: All HOCM patients undergoing SM + AMLE (2006-2015) and isolated SM (2015-2020) in our centre were analysed. The primary outcome was left ventricular outflow tract (LVOT)-gradient and surgical reoperation (SM/mitral surgery). Secondary outcomes were aortic cross-clamping (ACC) time, iatrogenic ventricular septal defect (VSD), and mortality at 30-day and 3-year follow-up. Mixed-effects models assessed postoperative changes in LVOT-gradient measurements over time until a 3-year follow-up. Results: This cohort ( Conclusion: HOCM-patients who underwent SM + AMLE had comparable clinical and echocardiographic outcomes to patients who underwent isolated SM. This suggests that increasing procedural complexity may not improve outcomes. However, given potential confounding, this should be interpreted with caution, future prospective randomised controlled trials are necessary.

Indexed as

Cardiomyopathy, HypertrophicMitral ValveSeptal MyectomyVentricular Outflow Obstruction, LeftAdultAgedFemaleHumansMaleMiddle AgedPostoperative ComplicationsRecovery of FunctionReoperationRetrospective StudiesRisk AssessmentRisk Factors

Identifiers

PMID41380732
PMCPMC13521660

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.