Evidence map›Paper›PMID 41380712›Full record

ReviewAnnual review of medicine2026

Peripheral Artery Disease: New Concepts, Treatments, and Disparities.

Samantha D Minc, Katharine L McGinigle

Abstract readReview
In one paragraph

Review in Annual review of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Samantha D MincDivision of Vascular and Endovascular Surgery, Department of Surgery, Duke University, Durham, North Carolina, USA; email: samantha.minc@duke.edu.
Katharine L McGinigleDivision of Vascular Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Funding

Implementing a Community-Engaged Amputation Prevention Intervention in Rural Patients with Diabetes and Peripheral Arterial DiseaseK23DK128569 · NIDDK · WEST VIRGINIA UNIVERSITY · PI MINC, SAMANTHA D · 2021 to 2025
$977k
Machine learning-based staging system to predict chronic limb-threatening ischemia disease progression and survival: A secondary analysis of the BEST-CLI trial dataR21HL172091 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCGINIGLE, KATHARINE L · 2024 to 2025
$233k
NHLBI NIH HHS R21 HL172091NIDDK NIH HHS K23 DK128569
6 · The paper itself

Abstract

Peripheral artery disease (PAD) is a prevalent and underdiagnosed atherosclerotic condition affecting more than 10 million adults in the United States. PAD is a marker of systemic vascular disease and a strong predictor of myocardial infarction, stroke, and mortality. Despite its clinical importance, PAD remains underrecognized due to variable presentation, limitations in screening, and disparities in diagnosis and treatment. This review examines contemporary PAD epidemiology, diagnostic strategies (including the ankle-brachial index), and evidence-based management approaches, from supervised exercise to surgical revascularization. It also highlights the evolving debate on PAD screening guidelines and presents emerging evidence favoring targeted screening in high-risk populations. Importantly, the review explores structural inequities, racial and ethnic disparities, and geographic variation in PAD-related outcomes, particularly amputation. These disparities persist even after adjustment for comorbidities and socioeconomic factors. Addressing PAD effectively requires comprehensive strategies that include early diagnosis, equitable access to care, and policy initiatives.

Indexed as

Healthcare DisparitiesPeripheral Arterial DiseaseAnkle Brachial IndexHumansMass ScreeningPrevalenceRisk FactorsUnited Statesamputationchronic limb-threatening ischemiaclaudicationdisparitiesperipheral artery diseasescreening

Identifiers

PMID41380712
PMCPMC12926866

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.