ArticleRedox biology2026
Combination of YAP inhibition and photodynamic therapy induces dual DNA damage and activates STING pathway to enhance immunotherapy in uveal melanoma.
Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- GSH-Responsive PBAE Polymers for IL-12 mRNA Delivery in Melanoma Immunotherapy.Investigative ophthalmology & visual science · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and is highly aggressive, with no therapies shown to improve overall survival. Although immunotherapy achieves response rates of 33-40 % in advanced cutaneous melanoma, its efficacy in UM is disappointingly low, with only 3.6 % of patients responding. Herein, we report a nanomedicine-based strategy to enhance immunotherapy efficacy in UM by strong activation of the cyclic guanosine 3',5'-cyclic monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway through dual deoxyribonucleic acid (DNA) damage induced by Yes-associated protein (YAP) inhibition and photodynamic therapy (PDT). This approach, using hyaluronic acid nanoparticle (HANP)-formulated verteporfin (HANP/VP), concurrently induced nuclear- and mitochondrial-DNA damage, promoted immunogenic cell death (ICD), and drove T-lymphocyte infiltration into the tumor microenvironment (TME). When combined with anti-programmed death-ligand 1 (anti-PD-L1) antibody (Ab) and laser radiation (690 nm, 200 mW/cm
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Registered trials
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