Evidence map›Paper›PMID 41380545›Full record

ReviewUltrasonics sonochemistry2026

Advances in ultrasound-assisted drug delivery and clinical application.

Limei Lai, Xiaoyu Han, Yunkai Tang, Jianqiao Zhou, Wenguo Cui

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Limei LaiDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China; Faculty of Medical Imaging Technology, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, 150 Ruijin 2nd Road, Shanghai 200025, China.
Xiaoyu HanDepartment of Rehabilitation Medicine, Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Yunkai TangDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China.
Jianqiao ZhouDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China; Faculty of Medical Imaging Technology, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, 150 Ruijin 2nd Road, Shanghai 200025, China. Electronic address: zhousu30@126.com.
Wenguo CuiDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China. Electronic address: wgcui@sjtu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultrasound (US) is a non-invasive physical stimulus  characterized by high spatiotemporal precision and deep tissue penetration, offering distinct advantages for drug delivery applications. This review provides a comprehensive overview of recent advances and future directions in ultrasound-assisted drug delivery (USADD) for diseases treatment. It systematically summarizes the fundamental mechanisms of USADD, including thermal effects, cavitation effects, and mechanical effects, and examines the design strategies of US-responsive carrier materials such as microbubbles, liposomes, polymeric micelles. Particular emphasis is placed on the therapeutic applications of USADD in a wide range of diseases, including tissue regeneration, cancer therapy, anti-infective therapies, cardiovascular disorders, immune-metabolic diseases, and conditions affecting the sensory organs. Finally, key challenges are discussed in clinical translation, including biosafety, carrier stability, and intelligent regulation, and future perspectives are outlined on the potential of USADD systems to achieve precise and personalized therapeutic interventions.

Indexed as

Drug Delivery SystemsUltrasonic WavesAnimalsHumansBiomaterialsCavitationDrug deliveryUltrasoundUltrasound-targeted microbubble destruction

Identifiers

PMID41380545
PMCPMC12752531

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.