Evidence map›Paper›PMID 41380244›Full record

ArticleEnvironment international2026

Does the timing of sample collection confound the association between prenatal serum PFAS concentrations and birthweight: results from two prospective cohort studies.

Xiaoyan Wu, Joseph M Braun, George D Papandonatos, Juan Tong, Hong Gan, Shuman Tao, Menglong Geng, Chunmei Liang, Aimin Chen, Kimberly Yolton and 4 more

Abstract read
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In one paragraph

Article in Environment international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Xiaoyan WuDepartment of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Hefei 230032 Anhui, China; Department of Epidemiology, Brown University, Providence, RI USA.
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, RI USA.
George D PapandonatosDepartment of Biostatistics, Brown University, Providence, RI USA.
Juan TongDepartment of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Hefei 230032 Anhui, China.
Hong GanDepartment of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Hefei 230032 Anhui, China.
Shuman TaoMOE Key Laboratory of Population Health Across Life Cycle, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Hefei 230032 Anhui, China.
Menglong GengDepartment of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Hefei 230032 Anhui, China.
Chunmei LiangMOE Key Laboratory of Population Health Across Life Cycle, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Hefei 230032 Anhui, China.
Aimin ChenDepartment of Biostatistics, Epidemiology & Informatics, University of Pennsylvania, Philadelphia, PA USA.
Kimberly YoltonDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH USA.
Bruce P LanphearFaculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.
Shuangqin YanDepartment of Child Healthcare, Ma'anshan Maternal and Child Healthcare Center, Ma'anshan 243011 Anhui, China.
Kun HuangDepartment of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Fangbiao TaoDepartment of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Hefei 230032 Anhui, China. Electronic address: fbtao@ahmu.edu.cn.

Funding

Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic HealthR01ES032836 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2021 to 2024
$2.4M
Prenatal PFAS Exposure and Adult Cardiometabolic DiseaseR01ES037335 · NIEHS · BROWN UNIVERSITY · PI Joseph M Braun · 2025 to 2026
$1.3M
NIEHS NIH HHS R01 ES032836NIEHS NIH HHS R01 ES037335
6 · The paper itself

Abstract

backgroundMaternal serum concentrations of per- and polyfluoroalkyl substances (PFAS) during pregnancy have been consistently associated with reduced birthweight. However, these associations may be confounded by the timing of sample collection due to pregnancy-related changes in pharmacokinetics that impact both serum PFAS concentrations and birthweight.

methodsWe measured nine serum PFAS concentrations in each trimester among 728 women in the MABC Study (Ma'anshan, China, enrolled 2013-2014). We estimated covariate-adjusted differences in birthweight for individual PFAS and their mixture, as well as percent change in PFAS by infant birthweight. We repeated our analyses in 70 women-infant dyads from the HOME Study (Cincinnati, Ohio, enrolled 2003-2006) with repeated PFAS measures in 2nd trimester and at delivery.

resultsAssociations of individual PFAS and their mixture with birthweight became more strongly inverse for measurements taken later in pregnancy. Each SD increase in log

conclusionsThese findings suggest that physiological changes in pregnancy may confound associations between serum PFAS and birthweight. Studies with PFAS measures later in pregnancy may overestimate the true effect of PFAS on fetal growth.

Indexed as

Birth WeightEnvironmental PollutantsFluorocarbonsMaternal ExposureAdultAlkanesulfonic AcidsChinaFemaleHumansInfant, NewbornOhioPregnancyProspective StudiesAlkanesulfonic AcidsEnvironmental PollutantsFluorocarbonsBirthweightCohort studyPFAS

Identifiers

PMID41380244
PMCPMC13069983

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