SynthesisPain2026
Systematic review and meta-analyses of nonpharmacological interventions for co-occurring chronic pain and posttraumatic stress disorder.
Synthesis in Pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- PTSD treatment impacts on pain: secondary analysis of sertraline, prolonged exposure, and their combination.European journal of psychotraumatology · 2026Trial
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
abstractChronic pain and posttraumatic stress disorder (PTSD) frequently co-occur; however, evidence for effective nonpharmacological treatments is limited, resulting in a guidance gap for clinicians. The aim of this systematic review with meta-analysis was to synthesize and analyze the evidence base for nonpharmacological interventions for chronic pain and posttraumatic stress symptoms. MEDLINE, Embase, PsycINFO, and the PTSD Repository were searched for randomized controlled trials of noninvasive, nonpharmacological interventions in adults with chronic pain, PTSD, or both published from January 1, 1988 to August 31, 2024. Studies reporting assessments of both pain intensity and PTSD symptoms were included, and the primary outcomes were change in pain intensity and PTSD symptom severity. Meta-analyses calculated standardized mean differences (SMDs) in change scores for PTSD symptom severity and pain intensity from pre- to posttreatment. Confidence in the evidence was assessed using Grading of Recommendations, Assessment, Development and Evaluation (GRADE). The study is registered with PROSPERO, CRD42024507881. We identified 30 eligible trials (N = 3245 participants). We found evidence (low quality) that trauma-focused treatments may improve both PTSD symptom severity (a medium effect; SMD -0·75, 95% CI -1·37 to -0·12) and pain intensity (a small effect; SMD -0·34, 95% CI -0·56 to -0·11). We found no significant effects for cognitive-behavioral therapies, mind-body therapies, or peripheral modulation interventions for either outcome. Most studies were methodologically weak. Our findings suggest that treatments targeting chronic pain and PTSD should, at minimum, include a trauma-focused therapy component. However, further research is required to develop effective treatments for co-occurring chronic pain and PTSD.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.