Evidence map›Paper›PMID 41379974›Full record

ArticleScience (New York, N.Y.)2025

Multispecies pangenomes reveal a pervasive influence of population size on structural variation.

Scott V Edwards, Bohao Fang, Danielle Khost, George E Kolyfetis, Rebecca G Cheek, Devon A DeRaad, Nancy Chen, John W Fitzpatrick, John E McCormack, W Chris Funk and 5 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Finding low-complexity DNA sequences with longdust.Bioinformatics (Oxford, England) · 2026
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Scott V EdwardsDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-2535-6217
Bohao FangDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-5283-067X
Danielle KhostInformatics Group, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-6936-8864
George E KolyfetisDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-9601-1526
Rebecca G CheekDepartment of Biology, Graduate Degree Program in Ecology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0002-7935-3153
Devon A DeRaadDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-3105-985X
Nancy ChenDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID 0000-0001-8966-3449
John W FitzpatrickCornell Lab of Ornithology, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-6330-8403
John E McCormackMoore Laboratory of Zoology, Occidental College, Los Angeles, CA, USA.
W Chris FunkDepartment of Biology, Graduate Degree Program in Ecology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0002-6466-3618
Cameron K GhalamborDepartment of Biology, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0003-2515-4981
Erik GarrisonDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0003-3821-631X
Andrea GuarracinoDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0001-9744-131X
Heng LiDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0003-4874-2874
Timothy B SacktonInformatics Group, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-1673-9216

Funding

The WashU-UCSC-EBI Human Genome Reference Center."U41HG010972 · NHGRI · WASHINGTON UNIVERSITY · PI Ira M Hall, Heng Li · 2019 to 2026
$24.9M
Pangenomics of nicotine abuse in the hybrid rat diversity panelU01DA057530 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Hao Chen, BURT M SHARP · 2023 to 2026
$2.8M
Statistical and high-throughput models of enhancer function and evolutionR01HG011485 · NHGRI · HARVARD UNIVERSITY · PI EDWARDS, SCOTT V., FARLEY, EMMA KIRSTEN · 2021 to 2024
$2.5M
Computational tools for precision genome editingR01HG013618 · NHGRI · BOSTON CHILDREN'S HOSPITAL · PI Daniel Evan Bauer, Luca Pinello · 2024 to 2026
$2.3M
Population genomics with pedigrees: new approaches for studying contemporary evolutionR35GM133412 · NIGMS · UNIVERSITY OF ROCHESTER · PI CHEN, NANCY · 2019 to 2023
$1.9M
Building Tools and Community to Make Pangenomes AccessibleU01HG013760 · NHGRI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GARRISON, ERIK · 2024 to 2024
$1.6M
NHGRI NIH HHS R01 HG011485NHGRI NIH HHS R01 HG013618NHGRI NIH HHS U01 HG013760NHGRI NIH HHS U41 HG010972NIDA NIH HHS U01 DA057530NIGMS NIH HHS R35 GM133412
6 · The paper itself

Abstract

Structural variants (SVs) are widespread in vertebrate genomes, yet their evolutionary dynamics remain poorly understood. Using 45 long-read de novo genome assemblies and pangenome tools, we analyze SVs among three closely related species of North American jays (

Indexed as

Evolution, MolecularGenomeGenomic Structural VariationPopulation DensityAnimalsDNA Copy Number VariationsGenome Size

Identifiers

PMID41379974
PMCPMC13295103

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.