Evidence map›Paper›PMID 41379847›Full record

SynthesisPLoS neglected tropical diseases2025

Risk factors and control of Opisthorchis viverrini in the Lower Mekong Basin: A systematic review.

Suji Y O'Connor, Mary Lorraine Mationg, Matthew J Kelly, Callum Lowe, Gail M Williams, Archie C A Clements, Banchob Sripa, Somphou Sayasone, Virak Khieu, Kinley Wangdi and 11 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Impact of Community-Based Health Education and Sanitation Interventions onInternational journal of environmental research and public health · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Suji Y O'ConnorNational Centre for Epidemiology and Population Health, Australian National University, Acton, Australian Capital Territory, Australia.ORCID 0000-0002-7657-839X
Mary Lorraine MationgNational Centre for Epidemiology and Population Health, Australian National University, Acton, Australian Capital Territory, Australia.
Matthew J KellyNational Centre for Epidemiology and Population Health, Australian National University, Acton, Australian Capital Territory, Australia.
Callum LoweNational Centre for Epidemiology and Population Health, Australian National University, Acton, Australian Capital Territory, Australia.
Gail M WilliamsSchool of Public Health, University of Queensland, Herston, Queensland, Australia.
Archie C A ClementsSchool of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom.
Banchob SripaDepartment of Tropical Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Somphou SayasoneLao Tropical and Public Health Institute, Ministry of Health, Vientiane, Lao People's Democratic Republic.
Virak KhieuNational Center for Parasitology, Entomology and Malaria Control, Ministry of Health, Phnom Penh, Cambodia.
Kinley WangdiNational Centre for Epidemiology and Population Health, Australian National University, Acton, Australian Capital Territory, Australia.
Donald E StewartSchool of Medicine and Dentistry, Griffith University, Nathan, Queensland, Australia.
Sirikachorn TangkawattanaTropical Disease Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Apiporn T SuwannatraiTropical Disease Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Vanthanom SavathdyLao Tropical and Public Health Institute, Ministry of Health, Vientiane, Lao People's Democratic Republic.
Visal KhieuNational Center for Parasitology, Entomology and Malaria Control, Ministry of Health, Phnom Penh, Cambodia.
Sean N GannonQIMR Berghofer, Herston, Queensland, Australia.
Peter OdermattSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Catherine A GordonQIMR Berghofer, Herston, Queensland, Australia.
Sangduan WannachartTropical Disease Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Donald P McManusQIMR Berghofer, Herston, Queensland, Australia.
Darren J GrayQIMR Berghofer, Herston, Queensland, Australia.

Funding

Australian Government Research Training Program Domestic ScholarshipAustralian National Health and Medical Research Council
6 · The paper itself

Abstract

backgroundOpisthorchis viverrini (OV) is a major public health concern in the Lower Mekong Basin. This study aimed to synthesize all field-based empirical research examining risk factors and control strategies for OV in the Lower Mekong Basin (LMB).

methodsWe performed a systematic review of published literature (1990-2024) on field-based OV studies that examined risk factors and control strategies in LMB. The literature search included two databases: PubMed and Scopus. We included field-based studies that analysed or reported on OV risk factors or control strategies using quantitative or mixed methods and were written in English. We excluded secondary research articles, laboratory-based research, qualitative only research and studies conducted outside LMB. All prospective studies underwent quality assessment using the Newcastle-Ottawa Scale or the Cochrane Risk of Bias tool II prior to final inclusion.

resultsWe identified 807 citations from PubMed and Scopus. From those, 56 studies were included in the review and three additional studies were identified from citation searches of included studies in the review. Studies were extracted and analysed by research focus. Among the included studies, 45 were conducted in Thailand, 11 in Laos, two in Vietnam, and one in Cambodia. Factors associated with OV infection were explored in 51 studies, and 11 studies reported on control strategies. General education was found to be an important protective factor for OV infection. Consumption of raw or undercooked fish was the most reported risk factor. Anthelmintic treatment was the primary control strategy across studies.

conclusionThis review summarises risk factors and control strategies reported in LMB since 1990. We found that sociodemographic, environmental, and economic factors were important predictors of OV infection. Given the multitude of risk factors for infection identified in this study and the complex lifecycle of OV, we recommend a One Health approach, that recognises the interconnectedness of human, animal and environmental health, for future health promotion and control strategies.

trial registrationPROSPERO registration ID: CRD42022357080.

Indexed as

OpisthorchiasisOpisthorchisAnimalsAnthelminticsCambodiaHumansLaosRisk FactorsThailandVietnamAnthelmintics

Identifiers

PMID41379847
PMCPMC12698015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.