ArticleNeuroepidemiology2025
Environmental Factors and Risk of Early-Onset Dementia: A Population-Based Case-Control Study.
Article in Neuroepidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Regulatory Variation at TERT and TERC Shows Limited Association with Early-Onset Alzheimer's Disease in Carriers of the Mexican Founder MutationMedical sciences (Basel, Switzerland) · 2026Article
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Authors and funding
15 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionDementia with symptom onset before the age of 65 is referred to as early-onset dementia (EOD). Many gaps exist regarding EOD etiology, including the role of environmental factors.
methodsWe conducted a population-based case-control study in Modena province, Northern Italy, enrolling and geocoding 326 EOD cases and 1,941 sex- and age-matched controls, to investigate the association of traffic-related benzene, green spaces around the place of residence, and exposure to artificial outdoor light at night (LAN). We used nonlinear modeling to assess the relation between environmental variables and disease risk, overall, and separately for Alzheimer's dementia (AD) and non-AD.
resultsGreen spaces generally showed an inverse association with EOD risk that was almost linear for AD and inverted U-shaped for non-AD. We observed a weak positive association between traffic-related benzene exposure and EOD risk that seemed limited to AD, with little change in risk for non-AD. Exposure to LAN showed an inverse linear association with small differences across the two disease subgroups. Analyses stratified by sex and age showed generally stronger (but statistically imprecise) associations in females and older individuals.
conclusionOverall, these results are consistent with some environmental influences on EOD risk, particularly with a beneficial effect of green spaces and LAN, as well as a possible adverse role of air pollution, particularly for AD.
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